Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4525680..4526276 Replicon chromosome
Accession NZ_CP077660
Organism Enterobacter cloacae complex sp. ECL78

Toxin (Protein)


Gene name PumA Uniprot ID A0A5D9Q9B8
Locus tag KQQ04_RS21595 Protein ID WP_003860348.1
Coordinates 4525680..4525982 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A837FG03
Locus tag KQQ04_RS21600 Protein ID WP_022650216.1
Coordinates 4525989..4526276 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQQ04_RS21575 4521899..4523248 + 1350 WP_003860344.1 lysine-sensitive aspartokinase 3 -
KQQ04_RS21580 4523342..4524286 + 945 WP_022650218.1 ketopantoate/pantoate/pantothenate transporter PanS -
KQQ04_RS21585 4524337..4524609 + 273 WP_003860346.1 DUF3811 domain-containing protein -
KQQ04_RS21590 4524610..4525482 - 873 WP_003860347.1 23S rRNA pseudouridine(2604) synthase RluF -
KQQ04_RS21595 4525680..4525982 + 303 WP_003860348.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQQ04_RS21600 4525989..4526276 + 288 WP_022650216.1 putative addiction module antidote protein Antitoxin
KQQ04_RS21605 4526273..4527904 - 1632 WP_003860350.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11393.20 Da        Isoelectric Point: 10.1042

>T207337 WP_003860348.1 NZ_CP077660:4525680-4525982 [Enterobacter cloacae complex sp. ECL78]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHLGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T207337 NZ_CP102961:c2138866-2138657 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10087.57 Da        Isoelectric Point: 5.7807

>AT207337 WP_022650216.1 NZ_CP077660:4525989-4526276 [Enterobacter cloacae complex sp. ECL78]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp

>AT207337 NZ_CP102961:c2139171-2138878 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5D9Q9B8

Antitoxin

Source ID Structure
AlphaFold DB A0A837FG03

References