207336

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4242256..4242959 Replicon chromosome
Accession NZ_CP077660
Organism Enterobacter cloacae complex sp. ECL78

Toxin (Protein)


Gene name ypjF Uniprot ID A0A8B5ZZ18
Locus tag KQQ04_RS20240 Protein ID WP_039268718.1
Coordinates 4242256..4242597 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8B5ZWQ9
Locus tag KQQ04_RS20245 Protein ID WP_039268717.1
Coordinates 4242618..4242959 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQQ04_RS20220 4238781..4239152 + 372 WP_022650323.1 hypothetical protein -
KQQ04_RS20225 4239210..4239677 - 468 WP_022650322.1 SymE family type I addiction module toxin -
KQQ04_RS20230 4239977..4240813 + 837 Protein_3973 HNH endonuclease -
KQQ04_RS20235 4240994..4242001 - 1008 WP_039268719.1 restriction endonuclease -
KQQ04_RS20240 4242256..4242597 - 342 WP_039268718.1 TA system toxin CbtA family protein Toxin
KQQ04_RS20245 4242618..4242959 - 342 WP_039268717.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KQQ04_RS20250 4242970..4243512 - 543 WP_045259572.1 DNA repair protein RadC -
KQQ04_RS20255 4243525..4243965 - 441 WP_039268716.1 antirestriction protein -
KQQ04_RS20260 4243996..4244817 - 822 WP_039268715.1 DUF932 domain-containing protein -
KQQ04_RS20265 4244938..4245411 - 474 WP_039268714.1 hypothetical protein -
KQQ04_RS20270 4245483..4245935 - 453 WP_039269148.1 hypothetical protein -
KQQ04_RS20275 4245971..4246687 - 717 WP_039268713.1 WYL domain-containing protein -
KQQ04_RS20280 4246931..4247806 - 876 WP_039268712.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fosA - 4235584..4289515 53931


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12772.83 Da        Isoelectric Point: 9.6548

>T207336 WP_039268718.1 NZ_CP077660:c4242597-4242256 [Enterobacter cloacae complex sp. ECL78]
MKTLPATTPQAAKLCLLPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T207336 NZ_CP102961:c2119261-2118899 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12729.40 Da        Isoelectric Point: 6.9460

>AT207336 WP_039268717.1 NZ_CP077660:c4242959-4242618 [Enterobacter cloacae complex sp. ECL78]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRVSITGKFSEAECLKLDVAFPHFISQMESMLTTGGMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp

>AT207336 NZ_CP102961:c2119428-2119258 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5ZZ18

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5ZWQ9

References