Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2549881..2550620 Replicon chromosome
Accession NZ_CP077660
Organism Enterobacter cloacae complex sp. ECL78

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag KQQ04_RS12110 Protein ID WP_003857133.1
Coordinates 2550135..2550620 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag KQQ04_RS12105 Protein ID WP_003857131.1
Coordinates 2549881..2550147 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQQ04_RS12085 2545357..2546343 + 987 WP_022651202.1 DUF979 domain-containing protein -
KQQ04_RS12090 2546353..2547348 + 996 WP_003857125.1 DUF2891 domain-containing protein -
KQQ04_RS12095 2547370..2548758 - 1389 WP_032645625.1 MFS transporter -
KQQ04_RS12100 2548888..2549817 + 930 WP_022651200.1 LysR family transcriptional regulator -
KQQ04_RS12105 2549881..2550147 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
KQQ04_RS12110 2550135..2550620 + 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
KQQ04_RS12115 2550995..2551474 + 480 WP_001542736.1 hypothetical protein -
KQQ04_RS12120 2551496..2552299 + 804 WP_039268887.1 TIGR02391 family protein -
KQQ04_RS12125 2552320..2553753 + 1434 WP_004016055.1 restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T207333 WP_003857133.1 NZ_CP077660:2550135-2550620 [Enterobacter cloacae complex sp. ECL78]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T207333 NZ_CP102960:c2484777-2484511 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT207333 WP_003857131.1 NZ_CP077660:2549881-2550147 [Enterobacter cloacae complex sp. ECL78]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT207333 NZ_CP102960:c2485034-2484777 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References