Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 936005..936662 Replicon chromosome
Accession NZ_CP077660
Organism Enterobacter cloacae complex sp. ECL78

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag KQQ04_RS04455 Protein ID WP_022649305.1
Coordinates 936252..936662 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag KQQ04_RS04450 Protein ID WP_003863437.1
Coordinates 936005..936271 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQQ04_RS04430 931437..932870 - 1434 WP_022651811.1 6-phospho-beta-glucosidase BglA -
KQQ04_RS04435 932987..933718 - 732 WP_003863431.1 MurR/RpiR family transcriptional regulator -
KQQ04_RS04440 933985..934644 + 660 WP_003863433.1 hemolysin III family protein -
KQQ04_RS04445 934730..935710 - 981 WP_003863435.1 tRNA-modifying protein YgfZ -
KQQ04_RS04450 936005..936271 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
KQQ04_RS04455 936252..936662 + 411 WP_022649305.1 protein YgfX Toxin
KQQ04_RS04460 936664..937185 - 522 WP_003863440.1 flavodoxin FldB -
KQQ04_RS04465 937287..938183 + 897 WP_022651809.1 site-specific tyrosine recombinase XerD -
KQQ04_RS04470 938212..938925 + 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KQQ04_RS04475 938931..940664 + 1734 WP_022651808.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T207323 WP_022649305.1 NZ_CP077660:936252-936662 [Enterobacter cloacae complex sp. ECL78]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T207323 NZ_CP102959:c1902694-1902542 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGACTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAACAAGACAGTCAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT207323 WP_003863437.1 NZ_CP077660:936005-936271 [Enterobacter cloacae complex sp. ECL78]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT207323 NZ_CP102959:c1903318-1902719 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References