Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3379096..3379753 Replicon chromosome
Accession NZ_CP077659
Organism Enterobacter cloacae complex sp. ECL72

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag KTH07_RS16325 Protein ID WP_017382887.1
Coordinates 3379096..3379506 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag KTH07_RS16330 Protein ID WP_003863437.1
Coordinates 3379487..3379753 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTH07_RS16305 3375094..3376827 - 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -
KTH07_RS16310 3376833..3377546 - 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KTH07_RS16315 3377575..3378471 - 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
KTH07_RS16320 3378573..3379094 + 522 WP_015571793.1 flavodoxin FldB -
KTH07_RS16325 3379096..3379506 - 411 WP_017382887.1 protein YgfX Toxin
KTH07_RS16330 3379487..3379753 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
KTH07_RS16335 3380048..3381028 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
KTH07_RS16340 3381141..3381801 - 661 Protein_3203 hemolysin III family protein -
KTH07_RS16345 3382068..3382799 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
KTH07_RS16350 3382916..3384349 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T207319 WP_017382887.1 NZ_CP077659:c3379506-3379096 [Enterobacter cloacae complex sp. ECL72]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T207319 NZ_CP102958:c2031355-2031146 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT207319 WP_003863437.1 NZ_CP077659:c3379753-3379487 [Enterobacter cloacae complex sp. ECL72]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT207319 NZ_CP102958:c2031660-2031367 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACACAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References