Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1839172..1839911 Replicon chromosome
Accession NZ_CP077659
Organism Enterobacter cloacae complex sp. ECL72

Toxin (Protein)


Gene name tacT Uniprot ID A0A822W909
Locus tag KTH07_RS08860 Protein ID WP_017382345.1
Coordinates 1839172..1839657 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag KTH07_RS08865 Protein ID WP_003857131.1
Coordinates 1839645..1839911 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTH07_RS08835 1834748..1835332 - 585 WP_017382349.1 GDP-mannose pyrophosphatase nudK -
KTH07_RS08840 1835419..1836177 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
KTH07_RS08845 1836282..1837574 + 1293 WP_023303742.1 glycosyl hydrolase family 28 protein -
KTH07_RS08850 1837574..1838188 + 615 WP_023303743.1 NUDIX hydrolase -
KTH07_RS08855 1838552..1839121 + 570 WP_017382346.1 hypothetical protein -
KTH07_RS08860 1839172..1839657 - 486 WP_017382345.1 GNAT family N-acetyltransferase Toxin
KTH07_RS08865 1839645..1839911 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
KTH07_RS08870 1839975..1840904 - 930 WP_023303744.1 LysR family transcriptional regulator -
KTH07_RS08875 1841034..1842422 + 1389 WP_032619651.1 MFS transporter -
KTH07_RS08880 1842444..1843439 - 996 WP_023303746.1 DUF2891 domain-containing protein -
KTH07_RS08885 1843449..1844435 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17510.21 Da        Isoelectric Point: 9.9658

>T207308 WP_017382345.1 NZ_CP077659:c1839657-1839172 [Enterobacter cloacae complex sp. ECL72]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARAFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T207308 NZ_CP102956:c2440083-2439817 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT207308 WP_003857131.1 NZ_CP077659:c1839911-1839645 [Enterobacter cloacae complex sp. ECL72]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT207308 NZ_CP102956:c2440334-2440083 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822W909

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References