Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 596460..597080 Replicon chromosome
Accession NZ_CP077659
Organism Enterobacter cloacae complex sp. ECL72

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag KTH07_RS02820 Protein ID WP_015571250.1
Coordinates 596460..596678 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag KTH07_RS02825 Protein ID WP_006809850.1
Coordinates 596706..597080 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTH07_RS02790 592472..592732 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
KTH07_RS02795 592735..592875 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
KTH07_RS02800 592872..593582 - 711 WP_023303201.1 GNAT family protein -
KTH07_RS02805 593684..595144 + 1461 WP_032620143.1 PLP-dependent aminotransferase family protein -
KTH07_RS02810 595116..595583 - 468 WP_017383209.1 YlaC family protein -
KTH07_RS02815 595700..596251 - 552 WP_023303203.1 maltose O-acetyltransferase -
KTH07_RS02820 596460..596678 - 219 WP_015571250.1 HHA domain-containing protein Toxin
KTH07_RS02825 596706..597080 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
KTH07_RS02830 597591..600737 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
KTH07_RS02835 600760..601953 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T207307 WP_015571250.1 NZ_CP077659:c596678-596460 [Enterobacter cloacae complex sp. ECL72]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T207307 NZ_CP102956:c2059161-2058952 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT207307 WP_006809850.1 NZ_CP077659:c597080-596706 [Enterobacter cloacae complex sp. ECL72]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT207307 NZ_CP102956:c2059466-2059173 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References