Detailed information of TA system TA207306

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 5653329..5653893
• Replicon: chromosome
• Accession: NZ_CP077658
• Organism: Streptomyces sp. GMY02

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: KQY30_RS23900
• Protein ID: WP_217308583.1
• Coordinates: 5653546..5653893 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A975TM47
• Locus tag: KQY30_RS23895
• Protein ID: WP_046496803.1
• Coordinates: 5653329..5653559 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQY30_RS23880 (KQY30_23880)	5649046..5649279	+	234	WP_046504706.1	hypothetical protein	-
KQY30_RS23885 (KQY30_23885)	5649457..5650461	-	1005	WP_217311286.1	MASE1 domain-containing protein	-
KQY30_RS23890 (KQY30_23890)	5650624..5653200	-	2577	WP_217308582.1	aminopeptidase N	-
KQY30_RS23895 (KQY30_23895)	5653329..5653559	+	231	WP_046496803.1	ribbon-helix-helix protein, CopG family	Antitoxin
KQY30_RS23900 (KQY30_23900)	5653546..5653893	+	348	WP_217308583.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
KQY30_RS23905 (KQY30_23905)	5654052..5655287	+	1236	WP_217308584.1	MFS transporter	-
KQY30_RS23910 (KQY30_23910)	5655268..5656305	-	1038	WP_217308585.1	aspartate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-112)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-38)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12559.42 Da
• Isoelectric Point: 10.8664

>T207306 WP_217308583.1 NZ_CP077658:5653546-5653893 [Streptomyces sp. GMY02]
MRRGDIFLIDFEPVRGSEANKARPAVVVSNDAANRSAERSGKGVVTVVPVTSNTARVFAFQVALPAEECGLTKDSKAQCE
QVRAVSPDRMRQRLGAVPKQRMTELDAALRRHLAL

Nucleotide

• Length: 348 bp

>T207306 NZ_CP102956:c2039556-2039194 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8181.82 Da
• Isoelectric Point: 3.7832

>AT207306 WP_046496803.1 NZ_CP077658:5653329-5653559 [Streptomyces sp. GMY02]
MKISVSLPEEDVSFVDQYAAASESASRSAVIHAAIELLRASRLEEDYAAAFEEWDASDDAAFWERTAGDGLADAQG

Nucleotide

• Length: 231 bp

>AT207306 NZ_CP102956:c2039723-2039553 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA