Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3865647..3866272 Replicon chromosome
Accession NZ_CP077649
Organism Escherichia coli strain ST865

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag KTN07_RS18555 Protein ID WP_000911329.1
Coordinates 3865874..3866272 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag KTN07_RS18550 Protein ID WP_000450524.1
Coordinates 3865647..3865874 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTN07_RS18525 (3861448) 3861448..3861918 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
KTN07_RS18530 (3861918) 3861918..3862490 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
KTN07_RS18535 (3862636) 3862636..3863514 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
KTN07_RS18540 (3863531) 3863531..3864565 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
KTN07_RS18545 (3864778) 3864778..3865491 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
KTN07_RS18550 (3865647) 3865647..3865874 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
KTN07_RS18555 (3865874) 3865874..3866272 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
KTN07_RS18560 (3866419) 3866419..3867282 + 864 WP_001267507.1 neutral zinc metallopeptidase -
KTN07_RS18565 (3867297) 3867297..3869312 + 2016 WP_000829332.1 tRNA cytosine(34) acetyltransferase TmcA -
KTN07_RS18570 (3869386) 3869386..3870084 + 699 WP_000679812.1 esterase -
KTN07_RS18575 (3870194) 3870194..3870394 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T207290 WP_000911329.1 NZ_CP077649:3865874-3866272 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T207290 NZ_CP102953:c2418385-2418119 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT207290 WP_000450524.1 NZ_CP077649:3865647-3865874 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT207290 NZ_CP102953:c2418636-2418385 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References