Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2795083..2795669 Replicon chromosome
Accession NZ_CP077649
Organism Escherichia coli strain ST865

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag KTN07_RS13235 Protein ID WP_042014162.1
Coordinates 2795083..2795313 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag KTN07_RS13240 Protein ID WP_000593555.1
Coordinates 2795310..2795669 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTN07_RS13225 (2791120) 2791120..2793855 + 2736 WP_028132003.1 ribosome-associated ATPase/putative transporter RbbA -
KTN07_RS13230 (2793855) 2793855..2794979 + 1125 WP_045171765.1 ABC transporter permease -
KTN07_RS13235 (2795083) 2795083..2795313 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
KTN07_RS13240 (2795310) 2795310..2795669 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KTN07_RS13245 (2795789) 2795789..2796190 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
KTN07_RS13250 (2796196) 2796196..2797002 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
KTN07_RS13255 (2796999) 2796999..2797763 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
KTN07_RS13260 (2797763) 2797763..2798596 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
KTN07_RS13265 (2798593) 2798593..2799537 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T207285 WP_042014162.1 NZ_CP077649:2795083-2795313 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T207285 NZ_CP102952:c2471561-2471295 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTTGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT207285 WP_000593555.1 NZ_CP077649:2795310-2795669 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT207285 NZ_CP102952:c2471818-2471561 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References