Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1289135..1289753 Replicon chromosome
Accession NZ_CP077649
Organism Escherichia coli strain ST865

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KTN07_RS06295 Protein ID WP_001291435.1
Coordinates 1289535..1289753 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KTN07_RS06290 Protein ID WP_000344800.1
Coordinates 1289135..1289509 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTN07_RS06280 (1284224) 1284224..1285417 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KTN07_RS06285 (1285440) 1285440..1288589 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
KTN07_RS06290 (1289135) 1289135..1289509 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KTN07_RS06295 (1289535) 1289535..1289753 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KTN07_RS06300 (1289925) 1289925..1290476 + 552 WP_000102564.1 maltose O-acetyltransferase -
KTN07_RS06305 (1290592) 1290592..1291062 + 471 WP_000136192.1 YlaC family protein -
KTN07_RS06310 (1291226) 1291226..1292776 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KTN07_RS06315 (1292818) 1292818..1293171 - 354 WP_000878141.1 DUF1428 family protein -
KTN07_RS06325 (1293550) 1293550..1293861 + 312 WP_000409911.1 MGMT family protein -
KTN07_RS06330 (1293892) 1293892..1294464 - 573 WP_217609420.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T207279 WP_001291435.1 NZ_CP077649:1289535-1289753 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T207279 NZ_CP102951:5611592-5612473 [Pseudomonas sp. LS1212]
ATGCAGCCTGCCATCTTCAACCACGATCCTGCGCCCACGGCCAAACTCGAGGCGCTGCTCGACAGCCAGTTTGCCCAGCG
CGAACTGGCAGTGGACGACGGCCGTCTGGCTATCCGTGAAGTCGGAACCGGCCCGGCCATCGTGCTGCTGCACGGGATCG
GCTCGGGCGCGGCGTCATGGTTGCAGGTGGCTTTGGCGCTGAGCCAGGACGCCCGGGTGATCGCCTGGGATGCACCTGGC
TATGGCGACTCCACGCCACTGGCCCATCCCGCACCTTCGGCCATGGATTACGCCGGGCGCCTGCTGCATATGCTCGACGC
GCTGGGCATCGAAACCTGTGTGCTGGTCGGCCATTCGCTCGGCGCCCTGACGGCGACGGCATTGGCCAGCAGCCAGCCGC
ATCGCGTCAGCCGGCTGGTGTTGATCAGCCCGGCCCGTGGCTATGGCGACCCTGCGCGAGAAACCCAGCGCCAGCAGGTG
CGCGCCAAGCGCCTGCAAACCCTGGAGTGCCTGGGCATCGCGCAAATGGCCCATGAACGTTGCGCCCATATGCTCTCCAG
CCGCGCCAGCAGCAGTGCCCTGGCCTGGGTGCAGTGGAACATGTCGCGGCTCAATCCTGCTGGTTATCGCCAGGCCATCG
AGCTGCTCTGCGGCGATGACCTGCTACGCCATGCACCGCTGTCAGTGCCTTGCGAAGTGCACTGTGGCGAAGCGGACGCG
ATTACCGCCCCTGAAGCCTGCCATGGCCTGGCCAAGTCACTGGCGGCGAGCTTCAGCCTGATTCCCGATGCCGGGCATGC
CAGCCCCATCGAACAACCCATTGTGGTGGCTGGGCGCCTGGCCCATGCCCTCAAAGAATCCCTGACAGGTAGCGCGCTAT
GA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT207279 WP_000344800.1 NZ_CP077649:1289135-1289509 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT207279 NZ_CP102951:5612470-5613297 [Pseudomonas sp. LS1212]
ATGAATGATTCGGATCTGTTGAAAGACACTCAGGACAAATACATCGTGCCGGGCCTGGAGCGCGGCCTGCTGTTGCTTTG
CGAGTTCAGCCGGCAAAACCGCACACTGACCGCCCCCGAACTGGCGCGGCGCCTGGAGCTGCCGCGCTCGACCATTTTCC
GCTTGCTGACCACCCTGGAAACCATGGGTTTCGTCACCCGCAGCGGCAATGAGTACCGGCTGGGCATGTCCGTGTTGCGC
CTGGGCTTCGAATACCTCGCCTCGCTGGAGCTGACCGAACTGGGCCAGCCATTGTTGGCGCGCCTGTGCGACCGCCTCAA
CTACCCGAGCAACCTGGTGGTGCGCGATGGCCGCTCGATCGTCTATGTGGCCAAGGTCTCGCCGCCCTCGGTGTTTTCCA
GCGCCGTCAATGTCGGCACGCGCCTGCCCGCCCATGCCACCGTGCTGGGCAGGATTCTGCTCGAGGACCTGACGCTGGCC
GAACTGCGCGACTTGTACCCCGAAGATCACCTGGAACAGTACTCGCCGTGCACACCGAAAACCGTGCTCGAGCTGTTCGA
CCTGGTGCAGGGCGACCGTCAACGCGGCTTCGTCAGCGGTGAAGGGTTCTTCGAGTCGGCCATCTCTACCGTAGCGGCGC
CGGTACGCGATCACACCAGCCGGATCGTCGCCGCTCTGGGCGTGACCATCCCCACCGTGCAGATCGGCCATGTGAACTTC
GAAGAGCTGCTCTCGCAGGTGCGCCGCAGCGCCGACGAATTGTCGCGCCTGCTCAACTACACCCCCAACGTCGGCCACAA
CCGCGTCACTGCGTTGATGAGGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References