Detailed information of TA system TA207277

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 135213..136801
• Replicon: chromosome
• Accession: NZ_CP077649
• Organism: Escherichia coli strain ST865

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A5F1UYE1
• Locus tag: KTN07_RS00700
• Protein ID: WP_001125468.1
• Coordinates: 135479..136801 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KTN07_RS00695
• Protein ID: WP_001296726.1
• Coordinates: 135213..135479 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTN07_RS00695 (135213)	135213..135479	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KTN07_RS00700 (135479)	135479..136801	+	1323	WP_001125468.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
KTN07_RS00705 (137113)	137113..137321	+	209	Protein_140	AraC family transcriptional regulator	-
KTN07_RS00710 (137753)	137753..138316	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
KTN07_RS00715 (138677)	138677..139387	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	135213..151300	16087

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49408.03 Da
• Isoelectric Point: 9.1203

>T207277 WP_001125468.1 NZ_CP077649:135479-136801 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKEVGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T207277 NZ_CP102951:c1710789-1710214 [Pseudomonas sp. LS1212]
ATGAGACACTCCCCCTTCACGGCAGTATTCGACGCTTGCGTACTTTATCCCGCTCCACTTCGCTCACTCCTCATGTGGTT
GAGCCTTACAGGTTTGTATCGGGCTCGCTGGACTGAACAAATACATGAAGAATGGAAGCGTAATCTTCTTATCAATCGAG
ACGACTTGACCAGGGAGCAGTTGGACCGCACTTCCGAGCTAATGGACAGGTCCATTCCTGATGCATTGGTCACAGGCTAT
GAATCCCTCTGTGCAGACTTGAGTCTGCCCGACCCTGACGATCGCCATGTGCTTGCTGCTGCAATCCGCTGCAAGGCTGA
GGTTATCGTGACCTTCAACTTGAAGGATTTCCCGGTCGAAAGGCTGGATGGCTACGACATTGAAGCGATACATCCCGACG
ATTTCATCGCGGATCTCTGGGATCTTGACCAAGCTGCAGTGCTCTCAGCTGTGCAAGACCAGCGGCGATCGTTGAAAAGT
CCGCCGATGACCGGGCAGCAATACCTCGAGATGATCCTGCGTCAGGGACTCACTCAAACAGTGAGGAACCTGACTCCTTA
CATAGGCATGCTTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT207277 WP_001296726.1 NZ_CP077649:135213-135479 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT207277 NZ_CP102951:c1711253-1710786 [Pseudomonas sp. LS1212]
ATGATCGCCACCGAGCTTTCCAGAACGATTCTTCCTGTAGAGCGAGAAGTGGCGGCAGCTACGGAAGGTCAACGCACGCT
CGCGACGTTCCTCTCTACCCAGCGCGAAACTCAACTCATAGAAATTTTCGACAAGGACGACAAGCCGCACAAGATCGAGC
TACCCACCTCTGCCTTACGTTTACTCGTCGATATTCTGGGAGAGCTTGCAATAGGCAACGCGGTGAAGGTAGTGCCAATT
CATGCAGAACTGACAACCCAGGAAGCCGCTGACCTGCTGAACGTTTCGCGTCCGCACCTGATCAAGCTGCTGGAGGAAGG
AGCTTTGCCATTTACCAGGACCGGCCGTCATCGCCGCGTTCGTTTCTCCGATTTGATGGCGTACAAACAGCATCGAGACG
AGGACAGTCGCCAGACCATGGAGTCATTGACCCAACTGGATCAGGAGCTTCGGATGGGCTATGAATGA

Structures

Toxin

• AlphaFold DB: A0A5F1UYE1