Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3866005..3866630 Replicon chromosome
Accession NZ_CP077646
Organism Escherichia coli strain ST866

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag KTN06_RS18570 Protein ID WP_000911329.1
Coordinates 3866232..3866630 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag KTN06_RS18565 Protein ID WP_000450524.1
Coordinates 3866005..3866232 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTN06_RS18540 (3861806) 3861806..3862276 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
KTN06_RS18545 (3862276) 3862276..3862848 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
KTN06_RS18550 (3862994) 3862994..3863872 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
KTN06_RS18555 (3863889) 3863889..3864923 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
KTN06_RS18560 (3865136) 3865136..3865849 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
KTN06_RS18565 (3866005) 3866005..3866232 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
KTN06_RS18570 (3866232) 3866232..3866630 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
KTN06_RS18575 (3866777) 3866777..3867640 + 864 WP_001267507.1 neutral zinc metallopeptidase -
KTN06_RS18580 (3867655) 3867655..3869670 + 2016 WP_000829332.1 tRNA cytosine(34) acetyltransferase TmcA -
KTN06_RS18585 (3869744) 3869744..3870442 + 699 WP_000679812.1 esterase -
KTN06_RS18590 (3870552) 3870552..3870752 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T207263 WP_000911329.1 NZ_CP077646:3866232-3866630 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T207263 NZ_CP102947:c4234444-4234067 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT207263 WP_000450524.1 NZ_CP077646:3866005-3866232 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT207263 NZ_CP102947:c4234902-4234534 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References