Detailed information of TA system TA207247

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1703403..1703938
• Replicon: chromosome
• Accession: NZ_CP077638
• Organism: Methylorubrum extorquens strain PA1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KQ926_RS08130
• Protein ID: WP_012253128.1
• Coordinates: 1703648..1703938 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: KQ926_RS08125
• Protein ID: WP_012253127.1
• Coordinates: 1703403..1703651 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ926_RS08105	1698623..1699285	-	663	WP_245268212.1	hypothetical protein	-
KQ926_RS08110	1699296..1699829	-	534	Protein_1578	DUF5691 domain-containing protein	-
KQ926_RS08115 (KQ926_08030)	1700204..1701571	-	1368	WP_012253125.1	SWIM zinc finger family protein	-
KQ926_RS08120 (KQ926_08035)	1701767..1703269	-	1503	WP_042508775.1	glucose-6-phosphate dehydrogenase	-
KQ926_RS08125 (KQ926_08040)	1703403..1703651	+	249	WP_012253127.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
KQ926_RS08130 (KQ926_08045)	1703648..1703938	+	291	WP_012253128.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KQ926_RS08135 (KQ926_08050)	1703996..1704658	+	663	WP_245268178.1	uracil-DNA glycosylase family protein	-
KQ926_RS08140 (KQ926_08055)	1704666..1706192	-	1527	WP_012253130.1	alginate export family protein	-
KQ926_RS08145 (KQ926_08060)	1706517..1707215	+	699	WP_012253131.1	orotidine-5'-phosphate decarboxylase	-
KQ926_RS08150 (KQ926_08065)	1707218..1707562	+	345	WP_003605408.1	DUF1330 domain-containing protein	-
KQ926_RS08155 (KQ926_08070)	1707582..1708205	-	624	WP_012253132.1	TetR/AcrR family transcriptional regulator	-
KQ926_RS08160 (KQ926_08075)	1708428..1708628	-	201	WP_003605412.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10921.45 Da
• Isoelectric Point: 9.0225

>T207247 WP_012253128.1 NZ_CP077638:1703648-1703938 [Methylorubrum extorquens]
MSVRLSPRARADLSRIWDDSAERWGADQADCYIRLLAGGFDRLAEDPARGLGADEIRKGYFRLSVGSHILFYRLGAEGGI
EVIRILHGRMDFKRHF

Nucleotide

• Length: 291 bp

>T207247 NZ_CP102947:290369-290896 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8974.00 Da
• Isoelectric Point: 4.5173

>AT207247 WP_012253127.1 NZ_CP077638:1703403-1703651 [Methylorubrum extorquens]
MPRNTSVSLGEHFAQFIDRQVEGGRYGSASEVVRAGLRLLEEQEAALDTLRAALIEGEESGPPELFDTEAFLREKRAGAI
RG

Nucleotide

• Length: 249 bp

>AT207247 NZ_CP102947:290096-290362 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA