Detailed information of TA system TA207244

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): virAT/YafQ(toxin)
• Location: 5512..6061
• Replicon: plasmid pR19.1007_38k
• Accession: NZ_CP077636
• Organism: Campylobacter jejuni strain R19.1007

Toxin (Protein)

• Gene name: virT
• Uniprot ID: A0A5T0ZCU7
• Locus tag: KTN75_RS09510
• Protein ID: WP_014517465.1
• Coordinates: 5786..6061 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: virA
• Uniprot ID: A0A5T1T0M3
• Locus tag: KTN75_RS09505
• Protein ID: WP_014517464.1
• Coordinates: 5512..5796 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTN75_RS09455 (KTN75_09455)	625..1053	+	429	WP_014517463.1	hypothetical protein	-
KTN75_RS09460 (KTN75_09460)	1525..1869	+	345	WP_011117579.1	hypothetical protein	-
KTN75_RS09465 (KTN75_09465)	1883..2191	+	309	WP_052835053.1	hypothetical protein	-
KTN75_RS09470 (KTN75_09470)	2201..2422	+	222	WP_011799395.1	hypothetical protein	-
KTN75_RS09475 (KTN75_09475)	2435..2830	+	396	WP_011117582.1	hypothetical protein	-
KTN75_RS09480 (KTN75_09480)	2903..3334	+	432	WP_217296015.1	hypothetical protein	-
KTN75_RS09485 (KTN75_09485)	3321..3752	+	432	WP_002815407.1	hypothetical protein	-
KTN75_RS09490 (KTN75_09490)	3960..4145	+	186	WP_004306057.1	hypothetical protein	-
KTN75_RS09495 (KTN75_09495)	4157..4327	+	171	WP_002815835.1	hypothetical protein	-
KTN75_RS09500 (KTN75_09500)	4926..5288	+	363	WP_025443372.1	hypothetical protein	-
KTN75_RS09505 (KTN75_09505)	5512..5796	+	285	WP_014517464.1	hypothetical protein	Antitoxin
KTN75_RS09510 (KTN75_09510)	5786..6061	+	276	WP_014517465.1	type II toxin-antitoxin system YafQ family toxin	Toxin
KTN75_RS09515 (KTN75_09515)	6175..6486	+	312	Protein_13	hypothetical protein	-
KTN75_RS09520 (KTN75_09520)	6794..8365	-	1572	WP_217296016.1	relaxase/mobilization nuclease domain-containing protein	-
KTN75_RS09525 (KTN75_09525)	9239..9544	+	306	WP_011799398.1	hypothetical protein	-
KTN75_RS09530 (KTN75_09530)	9544..9786	+	243	WP_052835045.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	virB4 / Cjp54 / virB8 / virB9 / virB10 / virB11 / virD4	1..38247	38247

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10872.64 Da
• Isoelectric Point: 10.2009

>T207244 WP_014517465.1 NZ_CP077636:5786-6061 [Campylobacter jejuni]
MQNKYSVTFSKRFKKDFKKINNNDKKILKKIVNKLANDEVLEEKYKDHALKGNYIGFRECHIKPDLLLVYRKNNDILELY
LANLGNHNNIF

Nucleotide

• Length: 276 bp

>T207244 NZ_CP102946:c5485059-5484781 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11082.46 Da
• Isoelectric Point: 8.3991

>AT207244 WP_014517464.1 NZ_CP077636:5512-5796 [Campylobacter jejuni]
MFDYSKYENATEKQLIHALTLAEKRAEKLNSQLKENNELFKFLQKKLKNSFNTKKTKKADQRRPELDEAIEDYKNGNVEH
YANVEEAFKALNAE

Nucleotide

• Length: 285 bp

>AT207244 NZ_CP102946:c5484769-5484464 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Structures

Toxin

• AlphaFold DB: A0A5T0ZCU7

Antitoxin

• AlphaFold DB: A0A5T1T0M3