Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 927878..928535 Replicon chromosome
Accession NZ_CP077429
Organism Klebsiella aerogenes strain NTT31XS

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag KSL85_RS04570 Protein ID WP_015369792.1
Coordinates 928125..928535 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag KSL85_RS04565 Protein ID WP_015369791.1
Coordinates 927878..928144 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSL85_RS04540 (KSL85_04540) 923105..924538 - 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -
KSL85_RS04545 (KSL85_04545) 924652..925386 - 735 WP_015703423.1 MurR/RpiR family transcriptional regulator -
KSL85_RS04550 (KSL85_04550) 925437..925748 + 312 WP_015703422.1 N(4)-acetylcytidine aminohydrolase -
KSL85_RS04555 (KSL85_04555) 925913..926572 + 660 WP_008806429.1 hemolysin III family protein -
KSL85_RS04560 (KSL85_04560) 926671..927654 - 984 WP_015703421.1 tRNA-modifying protein YgfZ -
KSL85_RS04565 (KSL85_04565) 927878..928144 + 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
KSL85_RS04570 (KSL85_04570) 928125..928535 + 411 WP_015369792.1 protein YgfX Toxin
KSL85_RS04575 (KSL85_04575) 928543..929064 - 522 WP_015369793.1 flavodoxin FldB -
KSL85_RS04580 (KSL85_04580) 929165..930061 + 897 WP_015703420.1 site-specific tyrosine recombinase XerD -
KSL85_RS04585 (KSL85_04585) 930084..930797 + 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KSL85_RS04590 (KSL85_04590) 930803..932536 + 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T207232 WP_015369792.1 NZ_CP077429:928125-928535 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T207232 NZ_CP102945:c2021546-2021295 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT207232 WP_015369791.1 NZ_CP077429:927878-928144 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207232 NZ_CP102945:c2021305-2021132 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGATGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References