Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 261696..262327 Replicon chromosome
Accession NZ_CP077429
Organism Klebsiella aerogenes strain NTT31XS

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H3FL31
Locus tag KSL85_RS01200 Protein ID WP_015703741.1
Coordinates 261696..261971 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H3FNK6
Locus tag KSL85_RS01205 Protein ID WP_015703740.1
Coordinates 261968..262327 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSL85_RS01180 (KSL85_01180) 256925..257260 + 336 WP_015703743.1 universal stress protein UspB -
KSL85_RS01185 (KSL85_01185) 257325..258821 - 1497 WP_015369272.1 inorganic phosphate transporter PitA -
KSL85_RS01190 (KSL85_01190) 259052..260245 + 1194 WP_015703742.1 NAD(P)/FAD-dependent oxidoreductase -
KSL85_RS01195 (KSL85_01195) 260286..261299 - 1014 WP_015369274.1 magnesium transporter -
KSL85_RS01200 (KSL85_01200) 261696..261971 + 276 WP_015703741.1 type II toxin-antitoxin system HicA family toxin Toxin
KSL85_RS01205 (KSL85_01205) 261968..262327 + 360 WP_015703740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KSL85_RS01210 (KSL85_01210) 262355..262756 - 402 WP_032709347.1 nickel-responsive transcriptional regulator NikR -
KSL85_RS01215 (KSL85_01215) 262744..263535 - 792 WP_032709345.1 nickel import ATP-binding protein NikE -
KSL85_RS01220 (KSL85_01220) 263532..264296 - 765 WP_015703737.1 nickel import ATP-binding protein NikD -
KSL85_RS01225 (KSL85_01225) 264296..265129 - 834 WP_015369278.1 nickel ABC transporter permease subunit NikC -
KSL85_RS01230 (KSL85_01230) 265126..266070 - 945 WP_015703735.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10258.89 Da        Isoelectric Point: 10.4888

>T207231 WP_015703741.1 NZ_CP077429:261696-261971 [Klebsiella aerogenes]
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T207231 NZ_CP102945:c1996719-1996543 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13305.02 Da        Isoelectric Point: 4.3472

>AT207231 WP_015703740.1 NZ_CP077429:261968-262327 [Klebsiella aerogenes]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp

>AT207231 NZ_CP102945:1996420-1996475 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FL31

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FNK6

References