Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 1074824..1075362 | Replicon | chromosome |
| Accession | NZ_CP077425 | ||
| Organism | Vibrio mimicus strain Y4 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | KSS82_RS05170 | Protein ID | WP_000802134.1 |
| Coordinates | 1074824..1075123 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A271VK51 |
| Locus tag | KSS82_RS05175 | Protein ID | WP_001107720.1 |
| Coordinates | 1075120..1075362 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KSS82_RS05145 (KSS82_05145) | 1070308..1070694 | + | 387 | WP_217009270.1 | MmcQ/YjbR family DNA-binding protein | - |
| KSS82_RS05150 (KSS82_05150) | 1070849..1071853 | + | 1005 | WP_217009271.1 | LD-carboxypeptidase | - |
| KSS82_RS05155 (KSS82_05155) | 1072000..1072638 | + | 639 | WP_000230121.1 | HD domain-containing protein | - |
| KSS82_RS20665 | 1072695..1072757 | + | 63 | Protein_1057 | acetyltransferase | - |
| KSS82_RS05160 (KSS82_05160) | 1072802..1073194 | - | 393 | WP_217009272.1 | hypothetical protein | - |
| KSS82_RS05165 (KSS82_05165) | 1073195..1074478 | - | 1284 | WP_217009659.1 | hypothetical protein | - |
| KSS82_RS05170 (KSS82_05170) | 1074824..1075123 | - | 300 | WP_000802134.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KSS82_RS05175 (KSS82_05175) | 1075120..1075362 | - | 243 | WP_001107720.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| KSS82_RS05180 (KSS82_05180) | 1075638..1076492 | + | 855 | WP_217009273.1 | AAA family ATPase | - |
| KSS82_RS05185 (KSS82_05185) | 1076485..1076871 | + | 387 | WP_217009274.1 | hypothetical protein | - |
| KSS82_RS05190 (KSS82_05190) | 1077018..1077356 | + | 339 | WP_217009661.1 | hypothetical protein | - |
| KSS82_RS20670 | 1077732..1077788 | + | 57 | Protein_1065 | DUF645 family protein | - |
| KSS82_RS05200 (KSS82_05200) | 1078204..1078385 | + | 182 | Protein_1066 | DUF645 family protein | - |
| KSS82_RS20675 | 1078533..1078633 | + | 101 | Protein_1067 | acetyltransferase | - |
| KSS82_RS05205 (KSS82_05205) | 1078617..1078853 | - | 237 | WP_000772130.1 | RNA-binding protein | - |
| KSS82_RS20680 | 1079036..1079203 | + | 168 | Protein_1069 | acetyltransferase | - |
| KSS82_RS05210 (KSS82_05210) | 1079263..1079403 | + | 141 | WP_001952202.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | cqsA / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA | 1..1082609 | 1082608 | |
| - | inside | Genomic island | - | - | 980684..1079830 | 99146 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11601.34 Da Isoelectric Point: 9.9232
>T207230 WP_000802134.1 NZ_CP077425:c1075123-1074824 [Vibrio mimicus]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T207230 NZ_CP102945:c1895619-1895467 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8950.82 Da Isoelectric Point: 4.1677
>AT207230 WP_001107720.1 NZ_CP077425:c1075362-1075120 [Vibrio mimicus]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT207230 NZ_CP102945:c1896243-1895644 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|