Detailed information of TA system TA207228

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 1031609..1032393
• Replicon: chromosome
• Accession: NZ_CP077425
• Organism: Vibrio mimicus strain Y4

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: KSS82_RS04820
• Protein ID: WP_001114075.1
• Coordinates: 1031609..1031878 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: -
• Locus tag: KSS82_RS04825
• Protein ID: WP_217009248.1
• Coordinates: 1031872..1032393 (+)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSS82_RS04785 (KSS82_04785)	1026682..1027347	-	666	WP_123014081.1	hypothetical protein	-
KSS82_RS20580	1027268..1028023	-	756	WP_081096070.1	hypothetical protein	-
KSS82_RS04790 (KSS82_04790)	1028252..1028542	-	291	WP_005377002.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KSS82_RS04795 (KSS82_04795)	1028532..1028780	-	249	WP_005377003.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
KSS82_RS04800 (KSS82_04800)	1029196..1029315	+	120	WP_248341392.1	DUF645 family protein	-
KSS82_RS20585	1029759..1029869	+	111	WP_254219062.1	DUF3709 domain-containing protein	-
KSS82_RS04810 (KSS82_04810)	1030151..1030471	+	321	WP_217009246.1	hypothetical protein	-
KSS82_RS04815 (KSS82_04815)	1030619..1031398	+	780	WP_217009247.1	hypothetical protein	-
KSS82_RS04820 (KSS82_04820)	1031609..1031878	+	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
KSS82_RS04825 (KSS82_04825)	1031872..1032393	+	522	WP_217009248.1	DUF2442 domain-containing protein	Antitoxin
KSS82_RS20590	1032454..1032519	+	66	Protein_981	acetyltransferase	-
KSS82_RS04830 (KSS82_04830)	1032690..1032815	+	126	Protein_982	DUF645 family protein	-
KSS82_RS20595	1032781..1032897	+	117	WP_001952129.1	hypothetical protein	-
KSS82_RS04840 (KSS82_04840)	1033201..1034133	+	933	WP_002044844.1	hypothetical protein	-
KSS82_RS04845 (KSS82_04845)	1034117..1034545	+	429	WP_217009224.1	hypothetical protein	-
KSS82_RS04850 (KSS82_04850)	1034629..1034742	+	114	WP_217009249.1	iron transporter	-
KSS82_RS04855 (KSS82_04855)	1034708..1035190	+	483	WP_000422937.1	GNAT family protein	-
KSS82_RS04860 (KSS82_04860)	1035382..1035639	+	258	WP_217009250.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
KSS82_RS04865 (KSS82_04865)	1035627..1035929	+	303	WP_000807826.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KSS82_RS04870 (KSS82_04870)	1036243..1036425	+	183	WP_217009251.1	DUF645 family protein	-
KSS82_RS04875 (KSS82_04875)	1036626..1036973	+	348	WP_039485626.1	hypothetical protein	-
KSS82_RS20600	1036973..1037035	+	63	Protein_992	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	cqsA / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA	1..1082609	1082608
	-	inside	Genomic island	-	-	980684..1079830	99146

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Uncharacterized protein HI1420 (1-173)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T207228 WP_001114075.1 NZ_CP077425:1031609-1031878 [Vibrio mimicus]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T207228 NZ_CP102944:c5763762-5763484 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGACGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19374.99 Da
• Isoelectric Point: 6.7342

>AT207228 WP_217009248.1 NZ_CP077425:1031872-1032393 [Vibrio mimicus]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQLGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

>AT207228 NZ_CP102944:c5763472-5763167 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAATGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Structures

Toxin

• AlphaFold DB: A0A086SLD6