Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 1028252..1028780 | Replicon | chromosome |
| Accession | NZ_CP077425 | ||
| Organism | Vibrio mimicus strain Y4 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | K5TRR0 |
| Locus tag | KSS82_RS04790 | Protein ID | WP_005377002.1 |
| Coordinates | 1028252..1028542 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR02 |
| Locus tag | KSS82_RS04795 | Protein ID | WP_005377003.1 |
| Coordinates | 1028532..1028780 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KSS82_RS04765 (KSS82_04765) | 1023779..1024102 | + | 324 | WP_114975122.1 | DUF3709 domain-containing protein | - |
| KSS82_RS04770 (KSS82_04770) | 1024474..1025571 | + | 1098 | WP_217009244.1 | PAAR domain-containing protein | - |
| KSS82_RS04775 (KSS82_04775) | 1025571..1025975 | + | 405 | WP_217009245.1 | hypothetical protein | - |
| KSS82_RS20570 | 1025971..1026093 | + | 123 | WP_254219060.1 | DUF3265 domain-containing protein | - |
| KSS82_RS20575 | 1026083..1026211 | + | 129 | WP_254219061.1 | general secretion pathway protein GspI | - |
| KSS82_RS04780 (KSS82_04780) | 1026272..1026454 | + | 183 | WP_071186205.1 | DUF645 family protein | - |
| KSS82_RS04785 (KSS82_04785) | 1026682..1027347 | - | 666 | WP_123014081.1 | hypothetical protein | - |
| KSS82_RS20580 | 1027268..1028023 | - | 756 | WP_081096070.1 | hypothetical protein | - |
| KSS82_RS04790 (KSS82_04790) | 1028252..1028542 | - | 291 | WP_005377002.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KSS82_RS04795 (KSS82_04795) | 1028532..1028780 | - | 249 | WP_005377003.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KSS82_RS04800 (KSS82_04800) | 1029196..1029315 | + | 120 | WP_248341392.1 | DUF645 family protein | - |
| KSS82_RS20585 | 1029759..1029869 | + | 111 | WP_254219062.1 | DUF3709 domain-containing protein | - |
| KSS82_RS04810 (KSS82_04810) | 1030151..1030471 | + | 321 | WP_217009246.1 | hypothetical protein | - |
| KSS82_RS04815 (KSS82_04815) | 1030619..1031398 | + | 780 | WP_217009247.1 | hypothetical protein | - |
| KSS82_RS04820 (KSS82_04820) | 1031609..1031878 | + | 270 | WP_001114075.1 | DUF4160 domain-containing protein | - |
| KSS82_RS04825 (KSS82_04825) | 1031872..1032393 | + | 522 | WP_217009248.1 | DUF2442 domain-containing protein | - |
| KSS82_RS20590 | 1032454..1032519 | + | 66 | Protein_981 | acetyltransferase | - |
| KSS82_RS04830 (KSS82_04830) | 1032690..1032815 | + | 126 | Protein_982 | DUF645 family protein | - |
| KSS82_RS20595 | 1032781..1032897 | + | 117 | WP_001952129.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | cqsA / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA | 1..1082609 | 1082608 | |
| - | inside | Genomic island | - | - | 980684..1079830 | 99146 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11261.25 Da Isoelectric Point: 10.5932
>T207227 WP_005377002.1 NZ_CP077425:c1028542-1028252 [Vibrio mimicus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD
Download Length: 291 bp
>T207227 NZ_CP102944:c5549392-5549093 [Pseudomonas aeruginosa]
ATGGTTGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA
ATGGTTGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9079.37 Da Isoelectric Point: 3.9610
>AT207227 WP_005377003.1 NZ_CP077425:c1028780-1028532 [Vibrio mimicus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL
Download Length: 249 bp
>AT207227 NZ_CP102944:c5549096-5548806 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
CTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCTCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCGACATTGAAAACCATGCTGGCA
GTAATGCGAGCTTTGGGCGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
CTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCTCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCGACATTGAAAACCATGCTGGCA
GTAATGCGAGCTTTGGGCGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR03 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR02 |