Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 999662..1000227 | Replicon | chromosome |
| Accession | NZ_CP077425 | ||
| Organism | Vibrio mimicus strain Y4 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HCW8 |
| Locus tag | KSS82_RS04600 | Protein ID | WP_000869999.1 |
| Coordinates | 999940..1000227 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D0IIK3 |
| Locus tag | KSS82_RS04595 | Protein ID | WP_000086649.1 |
| Coordinates | 999662..999943 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KSS82_RS04550 (KSS82_04550) | 994970..995524 | + | 555 | WP_217009229.1 | hypothetical protein | - |
| KSS82_RS04555 (KSS82_04555) | 995821..995946 | + | 126 | Protein_914 | DUF645 family protein | - |
| KSS82_RS20490 | 995912..996028 | + | 117 | WP_001952129.1 | hypothetical protein | - |
| KSS82_RS20495 | 996119..996317 | + | 199 | Protein_916 | acetyltransferase | - |
| KSS82_RS04565 (KSS82_04565) | 996357..996482 | + | 126 | Protein_917 | DUF645 family protein | - |
| KSS82_RS20500 | 996466..996579 | + | 114 | WP_229600548.1 | cell shape-determining protein MreC | - |
| KSS82_RS04575 (KSS82_04575) | 996737..997378 | + | 642 | WP_000740022.1 | hypothetical protein | - |
| KSS82_RS04580 (KSS82_04580) | 997542..998177 | - | 636 | WP_217009231.1 | SDR family NAD(P)-dependent oxidoreductase | - |
| KSS82_RS20505 | 998327..998452 | + | 126 | WP_254219058.1 | C4-dicarboxylate ABC transporter | - |
| KSS82_RS04585 (KSS82_04585) | 998487..998912 | + | 426 | WP_217009232.1 | hypothetical protein | - |
| KSS82_RS20510 | 999283..999338 | + | 56 | Protein_923 | hypothetical protein | - |
| KSS82_RS20515 | 999325..999441 | + | 117 | WP_248342168.1 | Tfp pilus assembly protein | - |
| KSS82_RS04595 (KSS82_04595) | 999662..999943 | + | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KSS82_RS04600 (KSS82_04600) | 999940..1000227 | + | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KSS82_RS04605 (KSS82_04605) | 1000537..1000716 | + | 180 | WP_032471937.1 | DUF645 family protein | - |
| KSS82_RS04610 (KSS82_04610) | 1001319..1001807 | + | 489 | WP_142626769.1 | hypothetical protein | - |
| KSS82_RS04615 (KSS82_04615) | 1001951..1002745 | + | 795 | WP_217009233.1 | lysis protein | - |
| KSS82_RS04620 (KSS82_04620) | 1002815..1004004 | + | 1190 | WP_088124793.1 | IS3 family transposase | - |
| KSS82_RS20520 | 1004124..1004195 | + | 72 | Protein_931 | DUF3265 domain-containing protein | - |
| KSS82_RS04625 (KSS82_04625) | 1004498..1004617 | + | 120 | WP_248341392.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | cqsA / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA | 1..1082609 | 1082608 | |
| - | inside | Genomic island | - | - | 980684..1079830 | 99146 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10997.74 Da Isoelectric Point: 6.0710
>T207226 WP_000869999.1 NZ_CP077425:999940-1000227 [Vibrio mimicus]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T207226 NZ_CP102944:c5549096-5548806 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
CTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCTCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCGACATTGAAAACCATGCTGGCA
GTAATGCGAGCTTTGGGCGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
CTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCTCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCGACATTGAAAACCATGCTGGCA
GTAATGCGAGCTTTGGGCGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10361.93 Da Isoelectric Point: 5.1548
>AT207226 WP_000086649.1 NZ_CP077425:999662-999943 [Vibrio mimicus]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT207226 NZ_CP102944:c5549392-5549093 [Pseudomonas aeruginosa]
ATGGTTGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA
ATGGTTGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3AEF1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UIW4 |