Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 985200..985728 | Replicon | chromosome |
| Accession | NZ_CP077425 | ||
| Organism | Vibrio mimicus strain Y4 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | H9L4R3 |
| Locus tag | KSS82_RS04460 | Protein ID | WP_000221352.1 |
| Coordinates | 985200..985490 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | KSS82_RS04465 | Protein ID | WP_000213182.1 |
| Coordinates | 985480..985728 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KSS82_RS04425 (KSS82_04425) | 980522..981073 | + | 552 | WP_217009654.1 | translation initiation factor IF-3 | - |
| KSS82_RS04430 (KSS82_04430) | 981177..981371 | + | 195 | WP_001885060.1 | 50S ribosomal protein L35 | - |
| KSS82_RS04435 (KSS82_04435) | 981413..981766 | + | 354 | WP_001138366.1 | 50S ribosomal protein L20 | - |
| KSS82_RS04440 (KSS82_04440) | 981848..982810 | - | 963 | WP_000841995.1 | integron integrase IntIA | - |
| KSS82_RS04445 (KSS82_04445) | 983462..984193 | + | 732 | WP_217009223.1 | hypothetical protein | - |
| KSS82_RS04450 (KSS82_04450) | 984450..984623 | + | 174 | WP_157731315.1 | hypothetical protein | - |
| KSS82_RS04455 (KSS82_04455) | 984580..985050 | + | 471 | WP_138941939.1 | hypothetical protein | - |
| KSS82_RS04460 (KSS82_04460) | 985200..985490 | - | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KSS82_RS04465 (KSS82_04465) | 985480..985728 | - | 249 | WP_000213182.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KSS82_RS04470 (KSS82_04470) | 985925..986407 | + | 483 | WP_000422937.1 | GNAT family protein | - |
| KSS82_RS04475 (KSS82_04475) | 986704..986829 | + | 126 | Protein_899 | DUF645 family protein | - |
| KSS82_RS20485 | 986795..986911 | + | 117 | WP_001952129.1 | hypothetical protein | - |
| KSS82_RS04485 (KSS82_04485) | 987215..988147 | + | 933 | WP_002044844.1 | hypothetical protein | - |
| KSS82_RS04490 (KSS82_04490) | 988131..988559 | + | 429 | WP_217009224.1 | hypothetical protein | - |
| KSS82_RS04495 (KSS82_04495) | 988731..989489 | + | 759 | WP_217009225.1 | hypothetical protein | - |
| KSS82_RS04500 (KSS82_04500) | 989628..990074 | + | 447 | WP_000805118.1 | hypothetical protein | - |
| KSS82_RS04505 (KSS82_04505) | 990068..990187 | + | 120 | WP_127888672.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | cqsA / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA | 1..1082609 | 1082608 | |
| - | inside | Genomic island | - | - | 980684..1079830 | 99146 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11247.23 Da Isoelectric Point: 10.4678
>T207225 WP_000221352.1 NZ_CP077425:c985490-985200 [Vibrio mimicus]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
Download Length: 291 bp
>T207225 NZ_CP102944:c5146992-5146645 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8964.31 Da Isoelectric Point: 4.1079
>AT207225 WP_000213182.1 NZ_CP077425:c985728-985480 [Vibrio mimicus]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPANTYELMMDKLEDLELLAIAKERLSEDSVSVNID
DL
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPANTYELMMDKLEDLELLAIAKERLSEDSVSVNID
DL
Download Length: 249 bp
>AT207225 NZ_CP102944:c5147253-5147002 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|