207224

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /ElaA-DUF1778
Location 46960..47726 Replicon chromosome
Accession NZ_CP077425
Organism Vibrio mimicus strain Y4

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag KSS82_RS00395 Protein ID WP_217009295.1
Coordinates 46960..47457 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag KSS82_RS00400 Protein ID WP_000246254.1
Coordinates 47454..47726 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSS82_RS00350 (KSS82_00350) 43005..43094 + 90 Protein_76 type II toxin-antitoxin system death-on-curing family toxin -
KSS82_RS00355 (KSS82_00355) 43097..43207 + 111 WP_088129366.1 DUF3265 domain-containing protein -
KSS82_RS00360 (KSS82_00360) 43298..43579 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KSS82_RS00365 (KSS82_00365) 43576..43863 + 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin -
KSS82_RS00370 (KSS82_00370) 44021..44491 + 471 WP_217009293.1 GNAT family N-acetyltransferase -
KSS82_RS20455 44848..44903 + 56 Protein_81 hypothetical protein -
KSS82_RS20460 44890..45006 + 117 WP_248342168.1 Tfp pilus assembly protein -
KSS82_RS00380 (KSS82_00380) 45284..45457 + 174 WP_157731315.1 hypothetical protein -
KSS82_RS00385 (KSS82_00385) 45414..45884 + 471 WP_138941939.1 hypothetical protein -
KSS82_RS00390 (KSS82_00390) 46045..46818 + 774 WP_217009294.1 NERD domain-containing protein -
KSS82_RS00395 (KSS82_00395) 46960..47457 - 498 WP_217009295.1 GNAT family N-acetyltransferase Toxin
KSS82_RS00400 (KSS82_00400) 47454..47726 - 273 WP_000246254.1 DUF1778 domain-containing protein Antitoxin
KSS82_RS00405 (KSS82_00405) 47969..48490 + 522 WP_217009296.1 hypothetical protein -
KSS82_RS00410 (KSS82_00410) 48563..49249 - 687 Protein_89 IS30 family transposase -
KSS82_RS00415 (KSS82_00415) 49422..50504 + 1083 WP_217009297.1 calcium/sodium antiporter -
KSS82_RS00420 (KSS82_00420) 50614..52419 - 1806 WP_217009298.1 amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - cqsA / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA 1..1082609 1082608
- inside Prophage - - 36057..49225 13168
- flank IS/Tn - - 48563..49225 662


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-89)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18610.35 Da        Isoelectric Point: 8.7729

>T207224 WP_217009295.1 NZ_CP077425:c47457-46960 [Vibrio mimicus]
MMNTVLLDKFKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKDFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYEHYGFKAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T207224 NZ_CP102944:c4672025-4671270 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGGAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9685.19 Da        Isoelectric Point: 6.2988

>AT207224 WP_000246254.1 NZ_CP077425:c47726-47454 [Vibrio mimicus]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT207224 NZ_CP102944:c4672528-4672160 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References