Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 43298..43863 Replicon chromosome
Accession NZ_CP077425
Organism Vibrio mimicus strain Y4

Toxin (Protein)


Gene name relE Uniprot ID D7HCW8
Locus tag KSS82_RS00365 Protein ID WP_000869999.1
Coordinates 43576..43863 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0IIK3
Locus tag KSS82_RS00360 Protein ID WP_000086649.1
Coordinates 43298..43579 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSS82_RS00320 (KSS82_00320) 38571..39694 + 1124 WP_138041781.1 IS3 family transposase -
KSS82_RS00325 (KSS82_00325) 39896..40075 + 180 WP_032471937.1 DUF645 family protein -
KSS82_RS00330 (KSS82_00330) 40271..41077 + 807 WP_061051380.1 GIY-YIG nuclease family protein -
KSS82_RS00335 (KSS82_00335) 41248..41418 + 171 WP_001080654.1 hypothetical protein -
KSS82_RS00340 (KSS82_00340) 41418..41732 + 315 Protein_74 type II toxin-antitoxin system death-on-curing family toxin -
KSS82_RS00350 (KSS82_00350) 43005..43094 + 90 Protein_76 type II toxin-antitoxin system death-on-curing family toxin -
KSS82_RS00355 (KSS82_00355) 43097..43207 + 111 WP_088129366.1 DUF3265 domain-containing protein -
KSS82_RS00360 (KSS82_00360) 43298..43579 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KSS82_RS00365 (KSS82_00365) 43576..43863 + 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KSS82_RS00370 (KSS82_00370) 44021..44491 + 471 WP_217009293.1 GNAT family N-acetyltransferase -
KSS82_RS20455 44848..44903 + 56 Protein_81 hypothetical protein -
KSS82_RS20460 44890..45006 + 117 WP_248342168.1 Tfp pilus assembly protein -
KSS82_RS00380 (KSS82_00380) 45284..45457 + 174 WP_157731315.1 hypothetical protein -
KSS82_RS00385 (KSS82_00385) 45414..45884 + 471 WP_138941939.1 hypothetical protein -
KSS82_RS00390 (KSS82_00390) 46045..46818 + 774 WP_217009294.1 NERD domain-containing protein -
KSS82_RS00395 (KSS82_00395) 46960..47457 - 498 WP_217009295.1 GNAT family N-acetyltransferase -
KSS82_RS00400 (KSS82_00400) 47454..47726 - 273 WP_000246254.1 DUF1778 domain-containing protein -
KSS82_RS00405 (KSS82_00405) 47969..48490 + 522 WP_217009296.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - cqsA / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA 1..1082609 1082608
- inside Prophage - - 36057..49225 13168
- flank IS/Tn - - 48563..49225 662


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10997.74 Da        Isoelectric Point: 6.0710

>T207223 WP_000869999.1 NZ_CP077425:43576-43863 [Vibrio mimicus]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T207223 NZ_CP102944:3693378-3693956 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGTTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGATCGCGCACCGCTGTTCAAGACCCTGCGCGAGTTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10361.93 Da        Isoelectric Point: 5.1548

>AT207223 WP_000086649.1 NZ_CP077425:43298-43579 [Vibrio mimicus]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT207223 NZ_CP102944:3692736-3693290 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3AEF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UIW4

References