Detailed information of TA system TA207222

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 31147..31931
• Replicon: chromosome
• Accession: NZ_CP077425
• Organism: Vibrio mimicus strain Y4

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: -
• Locus tag: KSS82_RS00265
• Protein ID: WP_217009290.1
• Coordinates: 31147..31416 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: A0A5C9SSA7
• Locus tag: KSS82_RS00270
• Protein ID: WP_000921693.1
• Coordinates: 31410..31931 (+)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSS82_RS00225 (KSS82_00225)	26408..26686	-	279	WP_000578471.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
KSS82_RS00230 (KSS82_00230)	26683..26967	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
KSS82_RS20445	27083..27276	+	194	Protein_52	hypothetical protein	-
KSS82_RS00235 (KSS82_00235)	27312..27530	+	219	WP_217009288.1	DUF3709 domain-containing protein	-
KSS82_RS00240 (KSS82_00240)	27779..28096	-	318	WP_000077449.1	CcdB family protein	-
KSS82_RS00245 (KSS82_00245)	28096..28341	-	246	WP_001260797.1	type II toxin-antitoxin system CcdA family antitoxin	-
KSS82_RS00250 (KSS82_00250)	28644..29603	+	960	WP_230374814.1	hypothetical protein	-
KSS82_RS00255 (KSS82_00255)	29587..30015	+	429	WP_000074666.1	hypothetical protein	-
KSS82_RS00260 (KSS82_00260)	30178..30954	+	777	WP_217009289.1	phosphotransferase	-
KSS82_RS00265 (KSS82_00265)	31147..31416	+	270	WP_217009290.1	DUF4160 domain-containing protein	Toxin
KSS82_RS00270 (KSS82_00270)	31410..31931	+	522	WP_000921693.1	DUF2442 domain-containing protein	Antitoxin
KSS82_RS00280 (KSS82_00280)	32203..32436	+	234	WP_217009291.1	DUF3709 domain-containing protein	-
KSS82_RS00285 (KSS82_00285)	32703..33479	+	777	WP_217009292.1	phosphotransferase	-
KSS82_RS00290 (KSS82_00290)	33667..34182	+	516	WP_114709464.1	hypothetical protein	-
KSS82_RS00295 (KSS82_00295)	34320..34919	+	600	WP_114773482.1	pentapeptide repeat-containing protein	-
KSS82_RS00300 (KSS82_00300)	35688..35831	+	144	WP_254219064.1	DUF645 family protein	-
KSS82_RS00305 (KSS82_00305)	36057..36770	+	714	WP_000123659.1	Fic family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	cqsA / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA	1..1082609	1082608
	-	inside	Prophage	-	-	36057..49225	13168

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Protein of unknown function DUF2442 (4-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10354.97 Da
• Isoelectric Point: 6.6344

>T207222 WP_217009290.1 NZ_CP077425:31147-31416 [Vibrio mimicus]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGEFLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T207222 NZ_CP102944:1964414-1965001 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GACGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19394.94 Da
• Isoelectric Point: 6.2506

>AT207222 WP_000921693.1 NZ_CP077425:31410-31931 [Vibrio mimicus]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKNAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

>AT207222 NZ_CP102944:1965068-1965922 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAGCAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGACAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A5C9SSA7