Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5099881..5100548 Replicon chromosome
Accession NC_003919
Organism Xanthomonas axonopodis pv. citri str. 306

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag XAC_RS21760 Protein ID WP_005916679.1
Coordinates 5100132..5100548 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag XAC_RS21755 Protein ID WP_005916676.1
Coordinates 5099881..5100135 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XAC_RS25700 (XAC4309) 5096003..5096222 + 220 Protein_4257 RNA 2'-phosphotransferase -
XAC_RS21735 (XAC4310) 5096379..5097644 + 1266 WP_015463799.1 cardiolipin synthase B -
XAC_RS21740 (XAC4311) 5097670..5098197 - 528 WP_005916668.1 hypothetical protein -
XAC_RS21745 (XAC4312) 5098436..5098642 + 207 WP_003489327.1 hypothetical protein -
XAC_RS21750 (XAC4313) 5098629..5099735 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
XAC_RS21755 (XAC4314) 5099881..5100135 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
XAC_RS21760 (XAC4315) 5100132..5100548 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
XAC_RS25705 5100670..5100873 - 204 WP_125460668.1 hypothetical protein -
XAC_RS25710 5101001..5101213 - 213 WP_015472901.1 hypothetical protein -
XAC_RS21765 (XAC4316) 5101470..5103089 + 1620 WP_015463800.1 hypothetical protein -
XAC_RS21770 (XAC4317) 5103193..5103591 - 399 WP_004429277.1 DUF2384 domain-containing protein -
XAC_RS21775 (XAC4318) 5103907..5104338 + 432 WP_005922907.1 hypothetical protein -
XAC_RS24625 (XAC4319) 5104367..5104693 - 327 Protein_4269 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T20722 WP_005916679.1 NC_003919:5100132-5100548 [Xanthomonas citri pv. citri str. 306]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T20722 NC_003919:5100132-5100548 [Xanthomonas citri pv. citri str. 306]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT20722 WP_005916676.1 NC_003919:5099881-5100135 [Xanthomonas citri pv. citri str. 306]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT20722 NC_003919:5099881-5100135 [Xanthomonas citri pv. citri str. 306]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References