Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
| Location | 8127..8665 | Replicon | chromosome |
| Accession | NZ_CP077425 | ||
| Organism | Vibrio mimicus strain Y4 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | KSS82_RS00070 | Protein ID | WP_217009279.1 |
| Coordinates | 8127..8426 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A271VK51 |
| Locus tag | KSS82_RS00075 | Protein ID | WP_001107720.1 |
| Coordinates | 8423..8665 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KSS82_RS00035 (KSS82_00035) | 3554..4201 | + | 648 | WP_254219049.1 | GyrI-like domain-containing protein | - |
| KSS82_RS20410 | 4551..4598 | + | 48 | Protein_8 | DUF645 family protein | - |
| KSS82_RS20415 | 4603..4722 | + | 120 | WP_119781147.1 | cell shape-determining protein MreC | - |
| KSS82_RS20420 | 4791..4925 | + | 135 | WP_114807794.1 | acetyltransferase | - |
| KSS82_RS00045 (KSS82_00045) | 4909..5145 | - | 237 | WP_000772136.1 | RNA-binding protein | - |
| KSS82_RS00050 (KSS82_00050) | 5401..5772 | + | 372 | WP_001164077.1 | MazG nucleotide pyrophosphohydrolase domain-containing protein | - |
| KSS82_RS00055 (KSS82_00055) | 5795..6754 | - | 960 | WP_217009278.1 | IS30 family transposase | - |
| KSS82_RS00060 (KSS82_00060) | 7030..7383 | + | 354 | WP_207805190.1 | nuclear transport factor 2 family protein | - |
| KSS82_RS00065 (KSS82_00065) | 7527..8024 | + | 498 | WP_142565236.1 | GNAT family N-acetyltransferase | - |
| KSS82_RS00070 (KSS82_00070) | 8127..8426 | - | 300 | WP_217009279.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KSS82_RS00075 (KSS82_00075) | 8423..8665 | - | 243 | WP_001107720.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| KSS82_RS20425 | 9032..9121 | + | 90 | WP_001905720.1 | DUF645 family protein | - |
| KSS82_RS20430 | 9157..9213 | + | 57 | WP_088129470.1 | DUF645 family protein | - |
| KSS82_RS00085 (KSS82_00085) | 9411..10130 | + | 720 | WP_217009280.1 | hypothetical protein | - |
| KSS82_RS00090 (KSS82_00090) | 10233..10550 | - | 318 | WP_217009281.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KSS82_RS00095 (KSS82_00095) | 10569..10811 | - | 243 | WP_001961623.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| KSS82_RS00100 (KSS82_00100) | 11201..11382 | + | 182 | Protein_23 | DUF645 family protein | - |
| KSS82_RS00105 (KSS82_00105) | 11596..12171 | + | 576 | WP_217009282.1 | sugar O-acetyltransferase | - |
| KSS82_RS00110 (KSS82_00110) | 12468..12647 | + | 180 | WP_069730859.1 | DUF645 family protein | - |
| KSS82_RS00115 (KSS82_00115) | 12850..13608 | + | 759 | WP_217009225.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | cqsA / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA | 1..1082609 | 1082608 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11631.37 Da Isoelectric Point: 9.9232
>T207216 WP_217009279.1 NZ_CP077425:c8426-8127 [Vibrio mimicus]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDISKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDISKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T207216 NZ_CP102941:c151255-150944 [Klebsiella pneumoniae]
ATGCACATTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA
ATGCACATTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8950.82 Da Isoelectric Point: 4.1677
>AT207216 WP_001107720.1 NZ_CP077425:c8665-8423 [Vibrio mimicus]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT207216 NZ_CP102941:c150947-150528 [Klebsiella pneumoniae]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTCCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTCCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|