Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/DinJ(antitoxin)
Location 1629571..1630177 Replicon chromosome
Accession NZ_CP077423
Organism Streptococcus gallolyticus subsp. gallolyticus TX20005

Toxin (Protein)


Gene name parE Uniprot ID A0A1I7GRN0
Locus tag JGX27_RS08205 Protein ID WP_009854656.1
Coordinates 1629571..1629903 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1S5WDU6
Locus tag JGX27_RS08210 Protein ID WP_009854657.1
Coordinates 1629893..1630177 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGX27_RS08180 (JGX27_08180) 1625002..1625610 - 609 WP_009854651.1 VTT domain-containing protein -
JGX27_RS08185 (JGX27_08185) 1625858..1626160 - 303 WP_009854652.1 PepSY domain-containing protein -
JGX27_RS08190 (JGX27_08190) 1626403..1627851 - 1449 WP_012962239.1 HAMP domain-containing sensor histidine kinase -
JGX27_RS08195 (JGX27_08195) 1627880..1628572 - 693 WP_009854654.1 response regulator transcription factor -
JGX27_RS08200 (JGX27_08200) 1628678..1629556 - 879 WP_009854655.1 DUF3114 domain-containing protein -
JGX27_RS08205 (JGX27_08205) 1629571..1629903 - 333 WP_009854656.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
JGX27_RS08210 (JGX27_08210) 1629893..1630177 - 285 WP_009854657.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JGX27_RS08215 (JGX27_08215) 1630453..1630971 + 519 WP_009854658.1 TetR/AcrR family transcriptional regulator -
JGX27_RS08220 (JGX27_08220) 1631085..1632854 + 1770 WP_009854659.1 oleate hydratase -
JGX27_RS08225 (JGX27_08225) 1632984..1633802 - 819 WP_009854660.1 class C sortase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(8-55)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13018.00 Da        Isoelectric Point: 8.6852

>T207215 WP_009854656.1 NZ_CP077423:c1629903-1629571 [Streptococcus gallolyticus subsp. gallolyticus TX20005]
MDYKKYKLIYSQRVIDTLDDIYHYIANEIGSTINAKKKIASIRKDLQRLEFFPEGGFDADEKFGKCLDPKYKTRGLTLSK
DYIALYNILENEVRIAYLLPTRSDYMDLFR

Download         Length: 333 bp

>T207215 NZ_CP102940:c5247401-5247018 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11125.47 Da        Isoelectric Point: 4.7049

>AT207215 WP_009854657.1 NZ_CP077423:c1630177-1629893 [Streptococcus gallolyticus subsp. gallolyticus TX20005]
MALAYDKSYNLRTYQKIYNQAEKVFKENNLNTAQALNLFLKNVAETGQLNLKTEEELKREKLFKNLQAEIQQSYAEFDEG
KFYTDEDLVERYGL

Download         Length: 285 bp

>AT207215 NZ_CP102940:c5247643-5247401 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I7GRN0

Antitoxin

Source ID Structure
AlphaFold DB A0A1S5WDU6

References