Detailed information of TA system TA207213

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Txe-Axe/YoeB-RelB
• Location: 1128112..1128628
• Replicon: chromosome
• Accession: NZ_CP077423
• Organism: Streptococcus gallolyticus subsp. gallolyticus TX20005

Toxin (Protein)

• Gene name: Txe
• Uniprot ID: F5X0X3
• Locus tag: JGX27_RS05760
• Protein ID: WP_014620143.1
• Coordinates: 1128112..1128369 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: -
• Locus tag: JGX27_RS05765
• Protein ID: WP_013643111.1
• Coordinates: 1128362..1128628 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JGX27_RS05735 (JGX27_05735)	1123657..1124250	+	594	WP_231844086.1	TipC family immunity protein	-
JGX27_RS05740 (JGX27_05740)	1124433..1125281	-	849	WP_012961961.1	MurR/RpiR family transcriptional regulator	-
JGX27_RS05745 (JGX27_05745)	1125451..1126434	+	984	WP_009854176.1	Gfo/Idh/MocA family oxidoreductase	-
JGX27_RS05750 (JGX27_05750)	1126439..1126963	+	525	WP_009854177.1	heme-binding protein	-
JGX27_RS05755 (JGX27_05755)	1126984..1128042	+	1059	WP_009854178.1	Gfo/Idh/MocA family oxidoreductase	-
JGX27_RS05760 (JGX27_05760)	1128112..1128369	-	258	WP_014620143.1	Txe/YoeB family addiction module toxin	Toxin
JGX27_RS05765 (JGX27_05765)	1128362..1128628	-	267	WP_013643111.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JGX27_RS05770 (JGX27_05770)	1128792..1129124	+	333	WP_009854181.1	putative DNA-binding protein	-
JGX27_RS05775 (JGX27_05775)	1129195..1130760	+	1566	WP_009854182.1	signal recognition particle protein	-
JGX27_RS05780 (JGX27_05780)	1130826..1131842	-	1017	WP_009854183.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10277.64 Da
• Isoelectric Point: 8.7825

>T207213 WP_014620143.1 NZ_CP077423:c1128369-1128112 [Streptococcus gallolyticus subsp. gallolyticus TX20005]
MIKAWSDDAWNDYMYWYNQGNKATIKKINRLIKEIDRTPFTGIGKPEPLKHDLSGKWSRRITDEHRLIYSVDETTIYFYS
CKDHY

Nucleotide

• Length: 258 bp

>T207213 NZ_CP102940:c4649431-4648898 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10393.65 Da
• Isoelectric Point: 4.6290

>AT207213 WP_013643111.1 NZ_CP077423:c1128628-1128362 [Streptococcus gallolyticus subsp. gallolyticus TX20005]
MEVVAYSNFRQNLKHYMKQVNDDAEPLIVTSKNIDDTVVVLSKRDYDSMQETFRIMSNNYLMNKIKRGDEQFKAANFQTH
ELLEVDDD

Nucleotide

• Length: 267 bp

>AT207213 NZ_CP102940:c4649708-4649442 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: A0A1S5WCL9