Detailed information of TA system TA207212

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 649408..649894
• Replicon: chromosome
• Accession: NZ_CP077423
• Organism: Streptococcus gallolyticus subsp. gallolyticus TX20005

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1S5WAV3
• Locus tag: JGX27_RS03560
• Protein ID: WP_009853752.1
• Coordinates: 649625..649894 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JGX27_RS03555
• Protein ID: WP_009853751.1
• Coordinates: 649408..649635 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JGX27_RS03510 (JGX27_03510)	645111..645548	+	438	WP_009853742.1	hypothetical protein	-
JGX27_RS03515 (JGX27_03515)	645760..645942	+	183	WP_009853743.1	hypothetical protein	-
JGX27_RS03520 (JGX27_03520)	646039..646617	+	579	WP_009853744.1	hypothetical protein	-
JGX27_RS03525 (JGX27_03525)	646614..646904	+	291	WP_009853745.1	hypothetical protein	-
JGX27_RS03530 (JGX27_03530)	646874..647257	+	384	WP_009853746.1	replication protein	-
JGX27_RS03535 (JGX27_03535)	647232..647612	+	381	WP_009853747.1	hypothetical protein	-
JGX27_RS03540 (JGX27_03540)	647630..648010	+	381	WP_009853748.1	hypothetical protein	-
JGX27_RS03545 (JGX27_03545)	648148..648357	+	210	WP_009853749.1	hypothetical protein	-
JGX27_RS03550 (JGX27_03550)	648628..649167	-	540	WP_009853750.1	hypothetical protein	-
JGX27_RS03555 (JGX27_03555)	649408..649635	+	228	WP_009853751.1	DUF6290 family protein	Antitoxin
JGX27_RS03560 (JGX27_03560)	649625..649894	+	270	WP_009853752.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JGX27_RS03565 (JGX27_03565)	650274..650840	-	567	WP_009853753.1	DUF3267 domain-containing protein	-
JGX27_RS03570 (JGX27_03570)	651091..651612	+	522	WP_009853754.1	transcription repressor NadR	-
JGX27_RS03575 (JGX27_03575)	651809..652363	+	555	WP_043878534.1	hypothetical protein	-
JGX27_RS03580 (JGX27_03580)	652518..654671	+	2154	WP_009853756.1	penicillin-binding protein PBP2B	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	641475..650840	9365

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10554.64 Da
• Isoelectric Point: 10.4700

>T207212 WP_009853752.1 NZ_CP077423:649625-649894 [Streptococcus gallolyticus subsp. gallolyticus TX20005]
MTYRLVVSDKVKKQLKKMDKHVRLMLAKDMKKHLDGLENPRQIGKALIGQFKGLWRYRIGNYRVICDIMDDELVILAIEI
GHRKDIYKN

Nucleotide

• Length: 270 bp

>T207212 NZ_CP102940:4040750-4040968 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8731.78 Da
• Isoelectric Point: 4.2925

>AT207212 WP_009853751.1 NZ_CP077423:649408-649635 [Streptococcus gallolyticus subsp. gallolyticus TX20005]
MSIVSLRLNEKEEELFRSYSIHTGKTLSELFKTALAEQIENQLDYETGIQALKEFKKNPVTHSIDDIIEEFENDL

Nucleotide

• Length: 228 bp

>AT207212 NZ_CP102940:4040349-4040723 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: A0A1S5WAV3