Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1919242..1919795 Replicon chromosome
Accession NZ_CP077422
Organism Dickeya dadantii strain M2-3

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag KTF62_RS08600 Protein ID WP_224062858.1
Coordinates 1919481..1919795 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag KTF62_RS08595 Protein ID WP_224062857.1
Coordinates 1919242..1919478 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTF62_RS08580 (KTF62_08535) 1916030..1917178 + 1149 WP_224062855.1 PD-(D/E)XK nuclease family protein -
KTF62_RS08585 (KTF62_08540) 1917382..1917498 + 117 Protein_1667 IS630 family transposase -
KTF62_RS08590 (KTF62_08545) 1917978..1918922 + 945 WP_224062856.1 zincin-like metallopeptidase domain-containing protein -
KTF62_RS08595 (KTF62_08550) 1919242..1919478 + 237 WP_224062857.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
KTF62_RS08600 (KTF62_08555) 1919481..1919795 + 315 WP_224062858.1 CcdB family protein Toxin
KTF62_RS08605 (KTF62_08560) 1919792..1920544 - 753 WP_224062859.1 MobC family replication-relaxation protein -
KTF62_RS08610 (KTF62_08565) 1920553..1922289 - 1737 WP_224063031.1 type IV secretory system conjugative DNA transfer family protein -
KTF62_RS08615 (KTF62_08570) 1923055..1923357 - 303 WP_224062860.1 TrbM/KikA/MpfK family conjugal transfer protein -
KTF62_RS08620 (KTF62_08575) 1923398..1924414 - 1017 WP_224062861.1 P-type DNA transfer ATPase VirB11 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hcp / vgrG1 1895882..1953667 57785


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11551.48 Da        Isoelectric Point: 7.9859

>T207202 WP_224062858.1 NZ_CP077422:1919481-1919795 [Dickeya dadantii]
MQFTVYGNTGKSTIYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPERFVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGI

Download         Length: 315 bp

>T207202 NZ_CP102935:c26750-26394 [Acinetobacter sp. AOR07_HL]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9030.02 Da        Isoelectric Point: 6.4777

>AT207202 WP_224062857.1 NZ_CP077422:1919242-1919478 [Dickeya dadantii]
MTAKQRNTQSVTMTVERALLLRARQAGINLSATLTTALDAELRHHEANKWQEENREAIDALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT207202 NZ_CP102935:c26401-26099 [Acinetobacter sp. AOR07_HL]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References