Detailed information of TA system TA207200

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1252513..1253138
• Replicon: chromosome
• Accession: NZ_CP077422
• Organism: Dickeya dadantii strain M2-3

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: E0SD87
• Locus tag: KTF62_RS05755
• Protein ID: WP_009114000.1
• Coordinates: 1252513..1252716 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: E0SD88
• Locus tag: KTF62_RS05760
• Protein ID: WP_013316870.1
• Coordinates: 1252770..1253138 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTF62_RS05725 (KTF62_05695)	1248171..1248509	+	339	WP_002208627.1	P-II family nitrogen regulator	-
KTF62_RS05730 (KTF62_05700)	1248552..1249844	+	1293	WP_013316866.1	ammonium transporter AmtB	-
KTF62_RS05735 (KTF62_05705)	1249939..1250802	-	864	WP_038900569.1	acyl-CoA thioesterase II	-
KTF62_RS05740 (KTF62_05710)	1251037..1251594	+	558	WP_224062704.1	YbaY family lipoprotein	-
KTF62_RS05745 (KTF62_05715)	1251625..1251954	-	330	WP_171852390.1	MGMT family protein	-
KTF62_RS05755 (KTF62_05725)	1252513..1252716	-	204	WP_009114000.1	HHA domain-containing protein	Toxin
KTF62_RS05760 (KTF62_05730)	1252770..1253138	-	369	WP_013316870.1	Hha toxicity modulator TomB	Antitoxin
KTF62_RS05765 (KTF62_05735)	1253646..1253789	-	144	WP_013316871.1	type B 50S ribosomal protein L36	-
KTF62_RS05770 (KTF62_05740)	1253805..1254056	-	252	WP_013316872.1	type B 50S ribosomal protein L31	-
KTF62_RS05775 (KTF62_05745)	1254236..1257382	-	3147	WP_013316873.1	efflux RND transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8133.51 Da
• Isoelectric Point: 8.8500

>T207200 WP_009114000.1 NZ_CP077422:c1252716-1252513 [Dickeya dadantii]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Nucleotide

• Length: 204 bp

>T207200 NZ_CP102933:c1242122-1241376 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTGAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCAGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14242.11 Da
• Isoelectric Point: 5.1811

>AT207200 WP_013316870.1 NZ_CP077422:c1253138-1252770 [Dickeya dadantii]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDTELRKWQKSKSQLFRMFSEKSICTVVKT

Nucleotide

• Length: 369 bp

>AT207200 NZ_CP102933:c1241375-1241205 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Structures

Toxin

• AlphaFold DB: A0A1X3RNQ0

Antitoxin

• AlphaFold DB: E0SD88