Detailed information of TA system TA207199

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 705049..705727
• Replicon: chromosome
• Accession: NZ_CP077422
• Organism: Dickeya dadantii strain M2-3

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: E0SLQ1
• Locus tag: KTF62_RS03315
• Protein ID: WP_013316362.1
• Coordinates: 705296..705727 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: KTF62_RS03310
• Protein ID: WP_013316361.1
• Coordinates: 705049..705315 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTF62_RS03290 (KTF62_03275)	701498..702148	+	651	WP_013316357.1	LysE family translocator	-
KTF62_RS03295 (KTF62_03280)	702218..702826	-	609	WP_013316358.1	HD domain-containing protein	-
KTF62_RS03300 (KTF62_03285)	703035..703685	+	651	WP_013316359.1	hemolysin III family protein	-
KTF62_RS03305 (KTF62_03290)	703758..704738	-	981	WP_013316360.1	tRNA-modifying protein YgfZ	-
KTF62_RS03310 (KTF62_03295)	705049..705315	+	267	WP_013316361.1	FAD assembly factor SdhE	Antitoxin
KTF62_RS03315 (KTF62_03300)	705296..705727	+	432	WP_013316362.1	protein YgfX	Toxin
KTF62_RS03320 (KTF62_03305)	705824..706342	-	519	WP_013316363.1	flavodoxin FldB	-
KTF62_RS03325 (KTF62_03310)	706471..707796	-	1326	WP_224062527.1	MFS transporter	-
KTF62_RS03330 (KTF62_03315)	708059..708958	+	900	WP_013316366.1	site-specific tyrosine recombinase XerD	-
KTF62_RS03335 (KTF62_03320)	709047..709763	+	717	WP_224062528.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16838.53 Da
• Isoelectric Point: 10.7687

>T207199 WP_013316362.1 NZ_CP077422:705296-705727 [Dickeya dadantii]
VAQWQCDLRVSWRMQLFSLLTHGFLVLMILLAPWPDGYAPLWLGLVTLVVFGFVFSQRIIKTRQGEISLHGENQLHWQQR
DWQIVRRPWLMRNGVLLSLRAVDGKGHQRLWLASDSMGNEEWRLLRQLLQQHSLQGTESSHHH

Nucleotide

• Length: 432 bp

>T207199 NZ_CP102933:490252-490602 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10476.98 Da
• Isoelectric Point: 5.5981

>AT207199 WP_013316361.1 NZ_CP077422:705049-705315 [Dickeya dadantii]
MDINNKSRIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQQFIRLLQCDDPDLFNWLMNHGEPVDPALKRMVSLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT207199 NZ_CP102933:489965-490246 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Structures

Toxin

• AlphaFold DB: E0SLQ1