Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4999386..5000971 Replicon chromosome
Accession NZ_CP077421
Organism Pectobacterium polaris strain QK413-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KSL88_RS22425 Protein ID WP_224072862.1
Coordinates 4999652..5000971 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KSL88_RS22420 Protein ID WP_039475230.1
Coordinates 4999386..4999652 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSL88_RS22395 (KSL88_22350) 4995037..4996539 - 1503 WP_224072860.1 MFS transporter -
KSL88_RS22400 (KSL88_22355) 4996643..4997194 + 552 WP_039551752.1 TetR/AcrR family transcriptional regulator -
KSL88_RS22405 (KSL88_22360) 4997240..4997635 - 396 WP_106389091.1 helix-turn-helix domain-containing protein -
KSL88_RS22410 (KSL88_22365) 4997778..4998629 + 852 WP_109412134.1 SDR family oxidoreductase -
KSL88_RS22415 (KSL88_22370) 4998687..4999250 - 564 WP_224072861.1 hypothetical protein -
KSL88_RS22420 (KSL88_22375) 4999386..4999652 + 267 WP_039475230.1 helix-turn-helix domain-containing protein Antitoxin
KSL88_RS22425 (KSL88_22380) 4999652..5000971 + 1320 WP_224072862.1 type II toxin-antitoxin system HipA family toxin Toxin
KSL88_RS22430 (KSL88_22385) 5001004..5002368 - 1365 WP_224072863.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
KSL88_RS22435 (KSL88_22390) 5002498..5004132 - 1635 WP_224072864.1 membrane protein insertase YidC -
KSL88_RS22440 (KSL88_22395) 5004135..5004392 - 258 WP_010281237.1 membrane protein insertion efficiency factor YidD -
KSL88_RS22445 (KSL88_22400) 5004356..5004715 - 360 WP_010281235.1 ribonuclease P protein component -
KSL88_RS22450 (KSL88_22405) 5004734..5004874 - 141 WP_005976668.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49268.46 Da        Isoelectric Point: 6.8254

>T207198 WP_224072862.1 NZ_CP077421:4999652-5000971 [Pectobacterium polaris]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHR
ADSTQPFDLLAKVGQDSVGALQLVPQGTPVHDIKKIEYKTLSEQQLENILTGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDHWRLPLNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPRCFMINAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVDPERDRYRFMQAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSRGKKYATEQIFPRHFFQTAKAVGFARESMENILVEFAHAI
DTVMTTVGSQLPVDFPTHISEAILAGLQARSRRLMSGWE

Download         Length: 1320 bp

>T207198 NZ_CP102932:c4554395-4554024 [Enterobacter sp. Crenshaw]
ATGGAGCACATGGCAGTGTTCGATACCAATATACTCATCGATCTTTTTAATAATCGCGTTGAGGCTGCGGATGCAATTGA
TCGCACAGCTTCTCATCGAGCCATTAGTCTGATCACATGGATGGAAGTCATGGTGGGGGCCCGCAAACATGGTCACGAAG
CGAAAACTGCGACAGTGATGGGCGTATTTGAGATTATTGATATCACCCGAGATATCGCTGAAAGAAGTGTAATTCTGCGC
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCTCAGAGCAGAAATTGTCCGTTGATTTCTCGAAA
CACGAAAGACTTTTCGGGCATTACTGGAGTCGTTTCACCTTACCAACTATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9917.18 Da        Isoelectric Point: 9.7281

>AT207198 WP_039475230.1 NZ_CP077421:4999386-4999652 [Pectobacterium polaris]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTTNNEASV
ASSWKEEW

Download         Length: 267 bp

>AT207198 NZ_CP102932:c4554640-4554398 [Enterobacter sp. Crenshaw]
ATAAGTCTTTCCGCGGATCTTGATATGGGCAGAATTCTGATCGATTTGTCTGATGACGTAATTCAACGACTGGATAATCT
GAAGCAGCTGCGTAACCGTCCTCGTGCCGAATTGCTTCGGGAAGCCATTGAGCAATATCTCGACCAGCAGAGTTCATCGG
TTATCCGCGATGCGCTTGGCTTGTGGGGAAACCAGCAGGAAGATGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References