207193

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4351668..4352251 Replicon chromosome
Accession NZ_CP077421
Organism Pectobacterium polaris strain QK413-1

Toxin (Protein)


Gene name parE Uniprot ID A0A7V8QAI8
Locus tag KSL88_RS19545 Protein ID WP_012822278.1
Coordinates 4351668..4351973 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7V8TMU0
Locus tag KSL88_RS19550 Protein ID WP_012822277.1
Coordinates 4351961..4352251 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSL88_RS19530 (KSL88_19475) 4348084..4349043 + 960 WP_224072640.1 ABC transporter permease -
KSL88_RS19535 (KSL88_19480) 4349036..4349902 + 867 WP_205556709.1 ABC transporter permease -
KSL88_RS19540 (KSL88_19485) 4349899..4351608 + 1710 WP_224072641.1 ABC transporter ATP-binding protein -
KSL88_RS19545 (KSL88_19490) 4351668..4351973 - 306 WP_012822278.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KSL88_RS19550 (KSL88_19495) 4351961..4352251 - 291 WP_012822277.1 ribbon-helix-helix protein, CopG family Antitoxin
KSL88_RS19555 (KSL88_19500) 4352313..4353167 - 855 WP_095701452.1 helix-turn-helix domain-containing protein -
KSL88_RS19560 (KSL88_19505) 4353192..4354031 - 840 WP_224072642.1 HTH-type transcriptional activator RhaS -
KSL88_RS19565 (KSL88_19510) 4354368..4355858 + 1491 WP_224072643.1 rhamnulokinase -
KSL88_RS19570 (KSL88_19515) 4355855..4357117 + 1263 WP_224072644.1 L-rhamnose isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-46)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11634.48 Da        Isoelectric Point: 9.4590

>T207193 WP_012822278.1 NZ_CP077421:c4351973-4351668 [Pectobacterium polaris]
MPQVIVSERARRDLQRLQDFLKNKNALAAKKAAEVLIRGIRQLEALPNIGRPVEHLPLEYQELVIEFGSSGYVMLYRHDE
LTDRVVILTVKHQKEAGYQNP

Download         Length: 306 bp

>T207193 NZ_CP102932:1639452-1639973 [Enterobacter sp. Crenshaw]
GTGGAGAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTATGACTTCGAGTATTTTGATTGTGGCGAACCCTCGCT
AAATGCCTTCCTTGCTGAACATCTGGTGCGTCAGCACAATGGGCGTATTTTACGAGCCTACCTGCTTAAAGAGCGCGATC
GTCCGCGTGTCCTGGGTTATTACACGTTATCGGGAAGCTGTTTTGAAAGAGCGATGCTTCCTTCTAAGACTCAGCAGCGC
CGGATCCCTTATATCAACGTACCCAGCGTGACGCTGGGACGTCTGGCTGTAGATAAAACCCTACAGGGAAACGAGTGGGG
AACAACGCTCGTTGCGCATGCTATGCGCGTTGTCTACCTGGCTTCACAGGCTGTGGGGGTACACGGAATATTTGTTGATG
CCCTTGACGAGCGGGCAAAACGATTTTATCTGAAGCAGGGCTTTATCCCGCTGACAGCTGAAAACAGCCATTCTTTGTTC
TTCCCTACAAAATCTATCGAACGGCTGTTTGAGCAAGAGTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11097.16 Da        Isoelectric Point: 4.7845

>AT207193 WP_012822277.1 NZ_CP077421:c4352251-4351961 [Pectobacterium polaris]
MADTPRQTTTLRIDQDIKERLKTLADDRHSSAHALMLEAIAEYVEREEKRSQYRKEALAAWEEYQNTGEHITADETVTWL
ESWGSGHEQDAPACHK

Download         Length: 291 bp

>AT207193 NZ_CP102932:1639176-1639445 [Enterobacter sp. Crenshaw]
ATGCCAGCACTTAAAAAACAGCGTATCGATCTTCGCTTAACGGACGAAGACAAAACAATGATTGAAGAAGCGGCGGCGAT
GACGAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCAGAGGTCATCGAGCAGCACCGTCGTC
TCGTATTAAACGAAGCATCATGGACTGCGGTGATGGATGCCATCGACAATCCGCCTGAGCCAAATGAACGCCTGAAACGA
GCAGCAAAACGGCTTCGAAACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8QAI8

Antitoxin

Source ID Structure
AlphaFold DB A0A7V8TMU0

References