Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 3789881..3790407 | Replicon | chromosome |
| Accession | NZ_CP077421 | ||
| Organism | Pectobacterium polaris strain QK413-1 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | - |
| Locus tag | KSL88_RS16995 | Protein ID | WP_224072418.1 |
| Coordinates | 3790102..3790407 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | C6C380 |
| Locus tag | KSL88_RS16990 | Protein ID | WP_015855076.1 |
| Coordinates | 3789881..3790099 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KSL88_RS22480 | 3785396..3785527 | - | 132 | WP_262252947.1 | hypothetical protein | - |
| KSL88_RS16960 (KSL88_16915) | 3786077..3787336 | + | 1260 | WP_224072413.1 | integrase arm-type DNA-binding domain-containing protein | - |
| KSL88_RS16965 (KSL88_16920) | 3787443..3787637 | - | 195 | WP_015854710.1 | YlcI/YnfO family protein | - |
| KSL88_RS16970 (KSL88_16925) | 3787823..3788164 | + | 342 | WP_224072414.1 | hypothetical protein | - |
| KSL88_RS16975 (KSL88_16930) | 3788157..3788345 | - | 189 | WP_224072415.1 | hypothetical protein | - |
| KSL88_RS16980 (KSL88_16935) | 3788767..3788937 | - | 171 | WP_224072416.1 | hypothetical protein | - |
| KSL88_RS16985 (KSL88_16940) | 3789079..3789822 | + | 744 | WP_224072417.1 | MobC family replication-relaxation protein | - |
| KSL88_RS16990 (KSL88_16945) | 3789881..3790099 | + | 219 | WP_015855076.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| KSL88_RS16995 (KSL88_16950) | 3790102..3790407 | + | 306 | WP_224072418.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| KSL88_RS17000 (KSL88_16955) | 3790759..3791676 | + | 918 | WP_224072419.1 | hypothetical protein | - |
| KSL88_RS17005 (KSL88_16960) | 3791680..3792081 | + | 402 | WP_224072420.1 | hypothetical protein | - |
| KSL88_RS17010 (KSL88_16965) | 3792713..3793747 | - | 1035 | WP_224072421.1 | IS110 family transposase | - |
| KSL88_RS17015 (KSL88_16970) | 3793870..3793950 | - | 81 | Protein_3329 | CopG family transcriptional regulator | - |
| KSL88_RS17020 (KSL88_16975) | 3794419..3794637 | + | 219 | WP_224072422.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| KSL88_RS17025 (KSL88_16980) | 3794640..3794945 | + | 306 | Protein_3331 | type II toxin-antitoxin system toxin CcdB | - |
| KSL88_RS17030 (KSL88_16985) | 3795056..3795268 | + | 213 | WP_224072423.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 3785900..3794207 | 8307 | |
| - | flank | IS/Tn | - | - | 3792713..3793747 | 1034 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11750.64 Da Isoelectric Point: 4.6873
>T207191 WP_224072418.1 NZ_CP077421:3790102-3790407 [Pectobacterium polaris]
MQFIVYGYKRASHYKMFVDVQSDIVETPKRRMVIPIIESHHLSEKVNKTLFPLIRIDGEDYRLMTMELSSVPVEVIGEEI
ADLGDYADEIKDAINLMFWGI
MQFIVYGYKRASHYKMFVDVQSDIVETPKRRMVIPIIESHHLSEKVNKTLFPLIRIDGEDYRLMTMELSSVPVEVIGEEI
ADLGDYADEIKDAINLMFWGI
Download Length: 306 bp
>T207191 NZ_CP102932:577663-577950 [Enterobacter sp. Crenshaw]
ATGCCAACGGAGTTTGAATGGGATACCAACAAAGCGAAAAGCAATCTCATTAAGCATGGGATTCGCTTTGAAGAAGCTGT
TCTGGTGTTTGACGATCCTTACCATTTATCTTTGCAGGATCGTCATGAAAATGGAGAGTTCCGTTGGCAGACCATTGGCC
TTGTACATGGTCTAATTGTCATTATGGTCGCACACACGGTACGTTTTGAAAGTGGTGACGAAGTCATTCGAATCATTAGC
GCACGAAAGGCGGACCGTAAAGAGAGGAACCGTTATGAGCATGGTTAA
ATGCCAACGGAGTTTGAATGGGATACCAACAAAGCGAAAAGCAATCTCATTAAGCATGGGATTCGCTTTGAAGAAGCTGT
TCTGGTGTTTGACGATCCTTACCATTTATCTTTGCAGGATCGTCATGAAAATGGAGAGTTCCGTTGGCAGACCATTGGCC
TTGTACATGGTCTAATTGTCATTATGGTCGCACACACGGTACGTTTTGAAAGTGGTGACGAAGTCATTCGAATCATTAGC
GCACGAAAGGCGGACCGTAAAGAGAGGAACCGTTATGAGCATGGTTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8178.13 Da Isoelectric Point: 7.0135
>AT207191 WP_015855076.1 NZ_CP077421:3789881-3790099 [Pectobacterium polaris]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENREGMEEVARFIAQNGSFADENRNW
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENREGMEEVARFIAQNGSFADENRNW
Download Length: 219 bp
>AT207191 NZ_CP102932:577937-578239 [Enterobacter sp. Crenshaw]
ATGAGCATGGTTAAATATAAACGCGGTAGTGCGCCTGAGATGAGTGCTCGCCGTGAGGCTGAGCTCAAAGCACTAGCCGA
AAAATCGGAAGCAGAGATTGATTACAGCGATATCCCTGCCATGGGAGATGAACAGTGGTCAGGGGCGGTGCGAGGGAAGT
TCTATCGGCCACTCAAAACTCAGGCGTCTGTACGTATCGACGCTGACGTGATGGAGTGGCTTAAACGGCCTGGAAAAGGT
TACCAGACGAGGCTCAATGCCATTTTGCGTGAAGCTATGCTGCGCGATCAAAACAAAAAATAA
ATGAGCATGGTTAAATATAAACGCGGTAGTGCGCCTGAGATGAGTGCTCGCCGTGAGGCTGAGCTCAAAGCACTAGCCGA
AAAATCGGAAGCAGAGATTGATTACAGCGATATCCCTGCCATGGGAGATGAACAGTGGTCAGGGGCGGTGCGAGGGAAGT
TCTATCGGCCACTCAAAACTCAGGCGTCTGTACGTATCGACGCTGACGTGATGGAGTGGCTTAAACGGCCTGGAAAAGGT
TACCAGACGAGGCTCAATGCCATTTTGCGTGAAGCTATGCTGCGCGATCAAAACAAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|