Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3539134..3539759 Replicon chromosome
Accession NZ_CP077421
Organism Pectobacterium polaris strain QK413-1

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag KSL88_RS15930 Protein ID WP_005976087.1
Coordinates 3539556..3539759 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag KSL88_RS15925 Protein ID WP_005976089.1
Coordinates 3539134..3539502 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSL88_RS15910 (KSL88_15865) 3534766..3537894 + 3129 WP_224072334.1 efflux RND transporter permease subunit -
KSL88_RS15915 (KSL88_15870) 3538127..3538375 + 249 WP_015839361.1 type B 50S ribosomal protein L31 -
KSL88_RS15920 (KSL88_15875) 3538393..3538536 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
KSL88_RS15925 (KSL88_15880) 3539134..3539502 + 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
KSL88_RS15930 (KSL88_15885) 3539556..3539759 + 204 WP_005976087.1 HHA domain-containing protein Toxin
KSL88_RS15940 (KSL88_15895) 3540503..3540823 + 321 WP_095993949.1 MGMT family protein -
KSL88_RS15945 (KSL88_15900) 3540843..3541424 - 582 WP_224072335.1 YbaY family lipoprotein -
KSL88_RS15950 (KSL88_15905) 3541637..3542500 + 864 WP_095698773.1 acyl-CoA thioesterase II -
KSL88_RS15955 (KSL88_15910) 3542637..3543923 - 1287 WP_167385195.1 ammonium transporter AmtB -
KSL88_RS15960 (KSL88_15915) 3543963..3544301 - 339 WP_039485501.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T207190 WP_005976087.1 NZ_CP077421:3539556-3539759 [Pectobacterium polaris]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T207190 NZ_CP102932:c258268-257966 [Enterobacter sp. Crenshaw]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCAACGCTGGGAGCAAAACTTAAAAGATCGGCGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGTTTAGCGGGCGACATTAAACCCGTTGGGGAAGGTATAAGTGAGCTGAGGATCC
ACTATGGTCCGGGCTACAGACTCTATTTTAAAGACCAGGGCAATTGCATCATCGTGCTGTTGTGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT207190 WP_005976089.1 NZ_CP077421:3539134-3539502 [Pectobacterium polaris]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT207190 NZ_CP102932:c257959-257672 [Enterobacter sp. Crenshaw]
ATGCATAAATTAACACCCTACGATCCAGCCAATGCGCTGGTGGATGACGAGGAAATCGCCGTGTTTATGGCTGATGCCTT
AGAAACGGGCGACTCAGCGTATATTGCTAAAGCGCTGGGCGTCATCGCGCGCGCGAAAGGAATGTCGACCATTTCACAGC
AAACTGGCCTATCACGAGAGCAACTGTATCGATCGTTCAGTGATAAAGGAAACCCAACGCTTAAAACCACTCTGGCGGTC
ATGAAAGCATTGGGTCTTGGGCTAACAATCAAACACGCTGGAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References