Detailed information of TA system TA207188

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 3146985..3147538
• Replicon: chromosome
• Accession: NZ_CP077421
• Organism: Pectobacterium polaris strain QK413-1

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: KSL88_RS14085
• Protein ID: WP_111778821.1
• Coordinates: 3146985..3147299 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A5S4UGL1
• Locus tag: KSL88_RS14090
• Protein ID: WP_010287128.1
• Coordinates: 3147302..3147538 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSL88_RS14050 (KSL88_14010)	3142132..3143994	+	1863	WP_111778816.1	type IV secretion system DNA-binding domain-containing protein	-
KSL88_RS14055 (KSL88_14015)	3144003..3144749	+	747	WP_111778817.1	MobC family replication-relaxation protein	-
KSL88_RS14060 (KSL88_14020)	3144876..3145241	-	366	WP_222850891.1	hypothetical protein	-
KSL88_RS14065 (KSL88_14025)	3145238..3145483	-	246	WP_111778818.1	hypothetical protein	-
KSL88_RS14070 (KSL88_14030)	3145476..3145703	-	228	WP_222850890.1	hypothetical protein	-
KSL88_RS14075 (KSL88_14035)	3145715..3146443	-	729	WP_181892574.1	ATP-binding protein	-
KSL88_RS14080	3146688..3146852	+	165	WP_224072152.1	hypothetical protein	-
KSL88_RS14085 (KSL88_14045)	3146985..3147299	-	315	WP_111778821.1	CcdB family protein	Toxin
KSL88_RS14090 (KSL88_14050)	3147302..3147538	-	237	WP_010287128.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
KSL88_RS14095 (KSL88_14055)	3147858..3148802	-	945	WP_224072153.1	zincin-like metallopeptidase domain-containing protein	-
KSL88_RS14100 (KSL88_14060)	3149392..3149682	+	291	WP_224072154.1	hypothetical protein	-
KSL88_RS14105 (KSL88_14065)	3149761..3151197	+	1437	WP_224072155.1	3'-5' exonuclease	-
KSL88_RS14110 (KSL88_14070)	3151194..3151844	+	651	WP_224072156.1	DarT ssDNA thymidine ADP-ribosyltransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3123818..3189070	65252

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11510.48 Da
• Isoelectric Point: 6.9727

>T207188 WP_111778821.1 NZ_CP077421:c3147299-3146985 [Pectobacterium polaris]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPIEKYPAGRRPDRLVPVVMLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRSQIKAAIDFLIDGF

Nucleotide

• Length: 315 bp

>T207188 NZ_CP102931:2459926-2460786 [Variovorax paradoxus]
ATGAACGACGCCATCGCCAGCGACGCGCTGACGCTGCCGGCCTCCGAGCTGGCGCGGCTCGACGCACGCTTTCCGGCCCG
CAATGTCGCGGTCGGCAGCGGTGCAGTGGTGTCGGTGCGCGAATGCGGCCAGGGCCCTGTCGTCGTGTGCCTGCACGGCA
TCGGCTCGGGTGCGGCGTCGTGGATCGACACCGCCGCGCTGCTCGCGTCCCAGGCCCGCGTGATTGCGTGGGACGCACCG
GGTTATGGCGAATCGACGCCGCTCGAAGCCGCCGCGCCGACAGCCGCCGACTACGCGGCACGTCTCAGCGCCTTGCTCGA
TGCACTCGGCATCGAGTCGTGCGTGCTGGTTGGCCATTCGCTCGGTGCGATCACCGCTGCCTCGGCTGCGCGCACAGATT
CGCGCATCCGCCGCCTCGTGCTCGTCAGCCCGGCCATCGGCTACGGCGCCCCGTCTCGCGCGGAGACTCGTGCCAAAGTG
CGCACCGAACGCCTTGCCACGCTCGACGAACTCGGCATCACCGGCATGGCCGCAAAGCGCGCGGGCCGGCTCGTCTCCGA
CAAGGCCAGCAACCACGCCCGCCAATGGGTGCGCTGGAACATGGCCCGGCTGAACGACCGCGGCTATCGCCAGGCCGTCG
AGCTGCTGTGCAACGCCGACCTGCTGGCCGACCTGCCGCCGCCCATGCCCGTACGTGTGGCCTGCGGCGCGCTCGACGTG
GTCACGCCGCCGGCGGCCTGCGAAGAAGTCGCGCGCCAGTGCGGCGTGCCGCTCGAATTGGTGGACGATGCAGGCCACGC
CGGCTATGTGGAGCAACCGCAGGCCGTCGCCGCACTGCTGCGCGAATCGCTCGCCGGCTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8998.01 Da
• Isoelectric Point: 5.6999

>AT207188 WP_010287128.1 NZ_CP077421:c3147538-3147302 [Pectobacterium polaris]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELRRHEAKIWQEENREAIDALNRFHDENGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT207188 NZ_CP102931:2460829-2461665 [Variovorax paradoxus]
ATGGCCAACAACGACAACGAGGCAATGGAAGAGGGCGCCGACCGCTACAACGTGCCCGCGCTGGAGCGTGGCCTGCGCGT
GCTGTGCGAGTTCAGCCGCGAAAGCCGCACGCTCTCCGCCCCCGAACTGGCCCGCCGCTTCGACCTGCCGCGCTCCACCG
TTTTCCGCCTGCTCACCACGCTGGAGAACATGGGTTTCCTCGAGCGCGCCGAGGGCGGGCGCGACTACCGCCTGGGCCTG
GCCGTGCTGCGCCTGGGTTTCGAATACCTCGCCTCGCTGGAGCTCACGCAACTGGGCACACCGCTGCTCAACCGCCTGTG
CGACGAACTGCGCACGCCCTGCAACCTGGTGGTACGCGATGGCCGTTCCATCGTCTACGTGGCCAAGGTCGCGCCGCCCA
CGCCCTTTGCCAGCTCGGTCACCGTGGGCACGCGCTTGCCGGCCCATGCCACCGTGCTCGGCCGCATCCTGCTCGAAGAC
CTCACGCTGCCGCAGCTGCGCGCGCTCTACCCTGAAGACAAGCTCGAAACCTTCTCGCCGAGCACGCCCAAGACCGTGAA
CGAACTCTTCGACATGGTGCAGGCCGACCGCCAGCGCGGCTATGTGTTGGGCGAAGGCTTCTTCGAGTCGAACATCTCCA
GCATCGCCGCGCCGGTGCGCGACCACAGCGGCCACATCGTGGCAGCGCTGGGCGCCACCATCACCTCGGACCACATCGAG
GAAAGCCGCATGGACGAGATGGTGCTGCGCGTGCGCGGCACGGCCGACGAGATCTCGGGGCTGCTCAACTACTCCCCAGC
GCGCGCCGCCAAGGTGGTGCCGCTTCGCAGCGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A5S4UGL1