Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 210925..211542 Replicon chromosome
Accession NZ_CP077421
Organism Pectobacterium polaris strain QK413-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KSL88_RS00870 Protein ID WP_095700916.1
Coordinates 211363..211542 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KSL88_RS00865 Protein ID WP_095700917.1
Coordinates 210925..211335 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSL88_RS00850 (KSL88_00850) 206797..207840 - 1044 WP_224072940.1 DNA-binding transcriptional regulator CytR -
KSL88_RS00855 (KSL88_00855) 208135..210333 - 2199 WP_224072941.1 primosomal protein N' -
KSL88_RS00860 (KSL88_00860) 210628..210843 + 216 WP_010281510.1 50S ribosomal protein L31 -
KSL88_RS00865 (KSL88_00865) 210925..211335 - 411 WP_095700917.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KSL88_RS00870 (KSL88_00870) 211363..211542 - 180 WP_095700916.1 type II toxin-antitoxin system HicA family toxin Toxin
KSL88_RS00875 (KSL88_00875) 211641..212651 - 1011 WP_224072942.1 iron ABC transporter permease -
KSL88_RS00880 (KSL88_00880) 212648..213610 - 963 WP_224072943.1 ABC transporter substrate-binding protein -
KSL88_RS00885 (KSL88_00885) 213620..214417 - 798 WP_095700913.1 ABC transporter ATP-binding protein -
KSL88_RS00890 (KSL88_00890) 214642..214959 - 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
KSL88_RS00895 (KSL88_00895) 215147..216307 + 1161 WP_039281157.1 cystathionine gamma-synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6550.65 Da        Isoelectric Point: 10.7838

>T207186 WP_095700916.1 NZ_CP077421:c211542-211363 [Pectobacterium polaris]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKSGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T207186 NZ_CP102929:c3974056-3973769 [Pseudomonas sp. CBS]
ATGACCTATAACCTTGAGTTTGATGCACGAGCGCTAAAGGAATGGCGCAAGCTTGGGGATACCGTACGTCAACAGCTCAA
GAAAAAGCTGGTTGAGATCCTGACCCATCCACGTATTGAAGCTAACCGGCTGCATGGTTTGCCCGACTGCTACAAAATCA
AGCTGCGTAGCAGCGGTTACCGGTTGGTCTATCAGGTGATTGATCAGGAGGTCATGGTATTTGTGGTGGCTGTCGATAAG
CGTGAGCGCGACGAGGTATATCGTAAAGCTACCGAGCGCTTGAGTTAG

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14487.39 Da        Isoelectric Point: 4.3391

>AT207186 WP_095700917.1 NZ_CP077421:c211335-210925 [Pectobacterium polaris]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPAVSSVGQLAKNAEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSAR

Download         Length: 411 bp

>AT207186 NZ_CP102929:c3974285-3974046 [Pseudomonas sp. CBS]
ATGGCCTCTATAAACATCCGTATCGACGACGACCTTAAAGCTCGCGCTTATCACGAGCTGGAAAAGTTGGGTGTCACCCC
TTCCGAATTGATGCGCCAAGCCCTGCAATATGTGGCTGAGCGCGGGCAATTACCGTTCAAGCCTGTTCTGATGACCGAGG
ACGATGAAGCCTTGTTGGCTACAGTTCGGGAACGGCTGGCTGCTCCCCAGCGAGTGAAGGTCTCACTGGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References