Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 6849..7375 Replicon plasmid unnamed2
Accession NZ_CP077412
Organism Enterobacter asburiae strain FDAARGOS 1432

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag I6L62_RS22440 Protein ID WP_000323025.1
Coordinates 6849..7136 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag I6L62_RS22445 Protein ID WP_004196370.1
Coordinates 7136..7375 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L62_RS22415 (I6L62_22415) 2222..2530 - 309 WP_023332865.1 DUF5983 family protein -
I6L62_RS22420 (I6L62_22420) 2596..3417 - 822 WP_023332864.1 DUF932 domain-containing protein -
I6L62_RS23655 3513..3648 - 136 Protein_5 single-stranded DNA-binding protein -
I6L62_RS23710 3815..3946 + 132 WP_255344245.1 hypothetical protein -
I6L62_RS22425 (I6L62_22425) 4228..5436 - 1209 WP_015386429.1 IS256 family transposase -
I6L62_RS22430 (I6L62_22430) 5535..5648 - 114 WP_233475035.1 DUF5431 family protein -
I6L62_RS22435 (I6L62_22435) 5764..6798 + 1035 Protein_9 IS481 family transposase -
I6L62_RS22440 (I6L62_22440) 6849..7136 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
I6L62_RS22445 (I6L62_22445) 7136..7375 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
I6L62_RS23660 7400..7498 + 99 Protein_12 hypothetical protein -
I6L62_RS22450 (I6L62_22450) 7658..8865 + 1208 WP_117086587.1 IS3 family transposase -
I6L62_RS22455 (I6L62_22455) 8977..9342 + 366 WP_009651956.1 hypothetical protein -
I6L62_RS22460 (I6L62_22460) 9386..10123 + 738 WP_008460272.1 HupE/UreJ family protein -
I6L62_RS22465 (I6L62_22465) 10137..10826 + 690 WP_004196322.1 hypothetical protein -
I6L62_RS22470 (I6L62_22470) 10857..12233 - 1377 Protein_17 chromate efflux transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..118412 118412
- inside IScluster/Tn - - 4228..8865 4637


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T207180 WP_000323025.1 NZ_CP077412:c7136-6849 [Enterobacter asburiae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T207180 NZ_CP077412:c7136-6849 [Enterobacter asburiae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT207180 WP_004196370.1 NZ_CP077412:c7375-7136 [Enterobacter asburiae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT207180 NZ_CP077412:c7375-7136 [Enterobacter asburiae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References