Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3225172..3225829 Replicon chromosome
Accession NZ_CP077411
Organism Enterobacter asburiae strain FDAARGOS 1432

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag I6L62_RS15320 Protein ID WP_021242050.1
Coordinates 3225172..3225582 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag I6L62_RS15325 Protein ID WP_010435322.1
Coordinates 3225563..3225829 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L62_RS15300 (I6L62_15300) 3221165..3222898 - 1734 WP_217071798.1 single-stranded-DNA-specific exonuclease RecJ -
I6L62_RS15305 (I6L62_15305) 3222904..3223617 - 714 WP_023309097.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6L62_RS15310 (I6L62_15310) 3223646..3224542 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
I6L62_RS15315 (I6L62_15315) 3224644..3225165 + 522 WP_217071799.1 flavodoxin FldB -
I6L62_RS15320 (I6L62_15320) 3225172..3225582 - 411 WP_021242050.1 protein YgfX Toxin
I6L62_RS15325 (I6L62_15325) 3225563..3225829 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
I6L62_RS15330 (I6L62_15330) 3226124..3227104 + 981 WP_033146590.1 tRNA-modifying protein YgfZ -
I6L62_RS15335 (I6L62_15335) 3227179..3227838 - 660 WP_033146591.1 hemolysin III family protein -
I6L62_RS15340 (I6L62_15340) 3228004..3228315 - 312 WP_047060448.1 N(4)-acetylcytidine aminohydrolase -
I6L62_RS15345 (I6L62_15345) 3228367..3229098 + 732 WP_032660101.1 MurR/RpiR family transcriptional regulator -
I6L62_RS15350 (I6L62_15350) 3229215..3230648 + 1434 WP_217071800.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T207177 WP_021242050.1 NZ_CP077411:c3225582-3225172 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T207177 NZ_CP102928:803378-803779 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT207177 WP_010435322.1 NZ_CP077411:c3225829-3225563 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207177 NZ_CP102928:803208-803378 [Vibrio cholerae]
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
TGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References