Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2312448..2313038 Replicon chromosome
Accession NZ_CP077411
Organism Enterobacter asburiae strain FDAARGOS 1432

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag I6L62_RS11145 Protein ID WP_032658722.1
Coordinates 2312448..2312780 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag I6L62_RS11150 Protein ID WP_033145928.1
Coordinates 2312781..2313038 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L62_RS11105 (I6L62_11105) 2308398..2308691 + 294 WP_000129503.1 hypothetical protein -
I6L62_RS11110 (I6L62_11110) 2308788..2309183 - 396 WP_024176586.1 hypothetical protein -
I6L62_RS11115 (I6L62_11115) 2309296..2309589 - 294 WP_049121561.1 hypothetical protein -
I6L62_RS11120 (I6L62_11120) 2309680..2309967 - 288 WP_088765788.1 hypothetical protein -
I6L62_RS11125 (I6L62_11125) 2309984..2310370 - 387 WP_048234408.1 hypothetical protein -
I6L62_RS11130 (I6L62_11130) 2310385..2310696 - 312 WP_001515481.1 hypothetical protein -
I6L62_RS11135 (I6L62_11135) 2310726..2310941 - 216 WP_000250489.1 AlpA family transcriptional regulator -
I6L62_RS11140 (I6L62_11140) 2311128..2311991 - 864 WP_032278482.1 DUF6387 family protein -
I6L62_RS11145 (I6L62_11145) 2312448..2312780 - 333 WP_032658722.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6L62_RS11150 (I6L62_11150) 2312781..2313038 - 258 WP_033145928.1 antitoxin Antitoxin
I6L62_RS11155 (I6L62_11155) 2313329..2313718 - 390 WP_059445031.1 RidA family protein -
I6L62_RS11160 (I6L62_11160) 2313860..2314780 + 921 WP_217073177.1 LysR family transcriptional regulator -
I6L62_RS11165 (I6L62_11165) 2314856..2315158 - 303 WP_029741460.1 XRE family transcriptional regulator -
I6L62_RS11170 (I6L62_11170) 2315163..2315516 - 354 WP_058841455.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6L62_RS11175 (I6L62_11175) 2315694..2316587 - 894 WP_217073178.1 LysR substrate-binding domain-containing protein -
I6L62_RS11180 (I6L62_11180) 2316758..2317366 + 609 WP_217073179.1 glutathione S-transferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2310726..2323579 12853


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11814.63 Da        Isoelectric Point: 9.4051

>T207174 WP_032658722.1 NZ_CP077411:c2312780-2312448 [Enterobacter asburiae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEGAGTTTTGVIRCDQPRTI
DMSARNGMRLERIPDAVVNEVLARLDAILN

Download         Length: 333 bp

>T207174 NZ_CP102928:778547-778834 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9464.92 Da        Isoelectric Point: 4.4737

>AT207174 WP_033145928.1 NZ_CP077411:c2313038-2312781 [Enterobacter asburiae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEEREWIDAPAV
GREIL

Download         Length: 258 bp

>AT207174 NZ_CP102928:778845-779162 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References