Detailed information of TA system TA207165

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): KacT-ataR/DUF1778(antitoxin)
• Location: 1053902..1054699
• Replicon: chromosome
• Accession: NZ_CP077411
• Organism: Enterobacter asburiae strain FDAARGOS 1432

Toxin (Protein)

• Gene name: KacT
• Uniprot ID: -
• Locus tag: I6L62_RS05040
• Protein ID: WP_233475018.1
• Coordinates: 1054178..1054699 (+)
• Length: 174 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: I6L62_RS05035
• Protein ID: WP_217072759.1
• Coordinates: 1053902..1054171 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L62_RS05005 (I6L62_05005)	1049529..1049972	-	444	WP_032658095.1	helix-turn-helix domain-containing protein	-
I6L62_RS05010 (I6L62_05010)	1050125..1051366	+	1242	WP_033145159.1	bifunctional glucose-1-phosphatase/inositol phosphatase	-
I6L62_RS05015 (I6L62_05015)	1051400..1051627	-	228	WP_008499832.1	YccJ family protein	-
I6L62_RS05020 (I6L62_05020)	1051648..1052244	-	597	WP_023311076.1	NAD(P)H:quinone oxidoreductase	-
I6L62_RS05025 (I6L62_05025)	1052635..1052805	+	171	WP_023311077.1	general stress protein	-
I6L62_RS05030 (I6L62_05030)	1052923..1053840	+	918	WP_217072758.1	DMT family transporter	-
I6L62_RS05035 (I6L62_05035)	1053902..1054171	+	270	WP_217072759.1	DUF1778 domain-containing protein	Antitoxin
I6L62_RS05040 (I6L62_05040)	1054178..1054699	+	522	WP_233475018.1	GNAT family N-acetyltransferase	Toxin
I6L62_RS05045 (I6L62_05045)	1054773..1056095	-	1323	WP_217072760.1	pyrimidine utilization transport protein G	-
I6L62_RS05050 (I6L62_05050)	1056117..1056611	-	495	WP_094934936.1	pyrimidine utilization flavin reductase protein F	-
I6L62_RS05055 (I6L62_05055)	1056621..1057211	-	591	WP_217072761.1	malonic semialdehyde reductase	-
I6L62_RS05060 (I6L62_05060)	1057221..1058021	-	801	WP_211437837.1	pyrimidine utilization protein D	-
I6L62_RS05065 (I6L62_05065)	1058029..1058415	-	387	WP_182403463.1	pyrimidine utilization protein C	-
I6L62_RS05070 (I6L62_05070)	1058427..1059116	-	690	WP_217072762.1	pyrimidine utilization protein B	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (2-88)

Sequences

Toxin

Protein

• Length: 174 a.a.
• Molecular weight: 19816.64 Da
• Isoelectric Point: 7.3809

>T207165 WP_233475018.1 NZ_CP077411:1054178-1054699 [Enterobacter asburiae]
VENLTIEMLSEGTDYDFEYFDCGEPSLNAFLAEHLVRQHNGRILRAYLLKERDRPRVLGYYTLSGSCFERAMLPSKTQQR
RIPYINVPSVTLGRLAVDKTLQGNEWGTTLVAHAMRVVYLASQAVGVHGLFVDALNERAKRFYLKQGFIPLTAENSHSLF
FPTKSIERLFEQE

Nucleotide

• Length: 522 bp

>T207165 NZ_CP102923:c6114-5809 [Klebsiella quasipneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGGCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10249.77 Da
• Isoelectric Point: 7.0181

>AT207165 WP_217072759.1 NZ_CP077411:1053902-1054171 [Enterobacter asburiae]
MPALKKKRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWTAVMDAIDNPPEPNERLKR
AAKRLRNME

Nucleotide

• Length: 270 bp

>AT207165 NZ_CP102923:c6334-6116 [Klebsiella quasipneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA