Detailed information of TA system TA207161

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 4714664..4715577
• Replicon: chromosome
• Accession: NZ_CP077407
• Organism: Enterobacter roggenkampii strain FDAARGOS 1430

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A8B2SFJ4
• Locus tag: I6L60_RS22255
• Protein ID: WP_045334129.1
• Coordinates: 4714664..4715137 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: I6L60_RS22260
• Protein ID: WP_069598066.1
• Coordinates: 4715134..4715577 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L60_RS22235 (I6L60_22235)	4710824..4712134	+	1311	WP_069598063.1	type I-F CRISPR-associated protein Csy1	-
I6L60_RS22240 (I6L60_22240)	4712131..4713066	+	936	WP_069598064.1	type I-F CRISPR-associated protein Csy2	-
I6L60_RS22245 (I6L60_22245)	4713080..4714078	+	999	WP_023327014.1	type I-F CRISPR-associated protein Csy3	-
I6L60_RS22250 (I6L60_22250)	4714088..4714642	+	555	WP_069598065.1	type I-F CRISPR-associated endoribonuclease Cas6/Csy4	-
I6L60_RS22255 (I6L60_22255)	4714664..4715137	-	474	WP_045334129.1	RES domain-containing protein	Toxin
I6L60_RS22260 (I6L60_22260)	4715134..4715577	-	444	WP_069598066.1	DUF2384 domain-containing protein	Antitoxin
I6L60_RS22265 (I6L60_22265)	4716916..4717134	-	219	WP_002211347.1	translation initiation factor IF-1	-
I6L60_RS22270 (I6L60_22270)	4717419..4718123	-	705	WP_008499991.1	leucyl/phenylalanyl-tRNA--protein transferase	-
I6L60_RS22275 (I6L60_22275)	4718169..4719890	-	1722	WP_069598067.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17539.85 Da
• Isoelectric Point: 5.0700

>T207161 WP_045334129.1 NZ_CP077407:c4715137-4714664 [Enterobacter roggenkampii]
MIFYRLVTGRYASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHVRKDTVLNQYQLFSIDIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPAFHSALNSVQQLPFIFDTRLAEKTAP

Nucleotide

• Length: 474 bp

>T207161 NZ_CP102921:c4629978-4629697 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGCTTGGCGAGACGGTCAAAAAACAGTTCAAAAA
TAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCTACAAAATCAAGC
TTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGGGTGGTGGTGGTTTACGTTATTGCCATTGGCAAAAGA
GAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16294.64 Da
• Isoelectric Point: 8.6042

>AT207161 WP_069598066.1 NZ_CP077407:c4715577-4715134 [Enterobacter roggenkampii]
MRTWIPAQKPADNALWRYAGLPANRGMRLIEFLNQGLPVSVLDNIHEWTSMSKADILRVTGINERNVARRKSAGRTLTPG
ESERVARFVRVLDAAVDYFGSKEEAWTWLQAPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT207161 NZ_CP102921:c4630210-4629968 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGACTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A8B2SFJ4