Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 3237152..3237813 Replicon chromosome
Accession NZ_CP077407
Organism Enterobacter roggenkampii strain FDAARGOS 1430

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I6L60_RS15415 Protein ID WP_023293716.1
Coordinates 3237415..3237813 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A837LFT0
Locus tag I6L60_RS15410 Protein ID WP_047748111.1
Coordinates 3237152..3237418 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L60_RS15385 (I6L60_15385) 3233206..3234534 - 1329 WP_023326395.1 PTS sugar transporter subunit IIC -
I6L60_RS15390 (I6L60_15390) 3234546..3234860 - 315 WP_008500132.1 PTS sugar transporter subunit IIB -
I6L60_RS15395 (I6L60_15395) 3235154..3236104 + 951 WP_069597711.1 LacI family DNA-binding transcriptional regulator -
I6L60_RS15400 (I6L60_15400) 3236166..3236462 - 297 WP_059365122.1 YicS family protein -
I6L60_RS15405 (I6L60_15405) 3236603..3237022 + 420 WP_069597712.1 GNAT family N-acetyltransferase -
I6L60_RS15410 (I6L60_15410) 3237152..3237418 + 267 WP_047748111.1 virulence protein Antitoxin
I6L60_RS15415 (I6L60_15415) 3237415..3237813 + 399 WP_023293716.1 type II toxin-antitoxin system VapC family toxin Toxin
I6L60_RS15420 (I6L60_15420) 3237953..3238753 + 801 WP_023293717.1 lipoprotein NlpA -
I6L60_RS15425 (I6L60_15425) 3238877..3239656 + 780 WP_069597713.1 MBL fold metallo-hydrolase -
I6L60_RS15430 (I6L60_15430) 3239683..3240636 + 954 WP_069597714.1 helix-turn-helix domain-containing protein -
I6L60_RS15435 (I6L60_15435) 3240819..3242516 + 1698 WP_235610634.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14799.00 Da        Isoelectric Point: 6.4779

>T207157 WP_023293716.1 NZ_CP077407:3237415-3237813 [Enterobacter roggenkampii]
MRHMLDTNIVSHLFKRHPEVVSRMTCLAPGDVCISSITEAELLYGADKKKSSRLKETIREFLNTITICDWDSDAAATYGE
LRATLEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFRMVQELAVEDWTTTL

Download         Length: 399 bp

>T207157 NZ_CP102921:1896707-1896809 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9950.31 Da        Isoelectric Point: 4.8145

>AT207157 WP_047748111.1 NZ_CP077407:3237152-3237418 [Enterobacter roggenkampii]
MERTAKLFKKGQNQAVMLPAEFAFNAESVYIRRDEEGNVVLAAKPVLIKSWDNFLRMLAETDVPDTFLSKEERNQSVTTR
DPLDGACS

Download         Length: 267 bp

>AT207157 NZ_CP102921:c1896813-1896666 [Klebsiella quasipneumoniae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837LFT0

References