Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2297592..2298249 Replicon chromosome
Accession NZ_CP077407
Organism Enterobacter roggenkampii strain FDAARGOS 1430

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag I6L60_RS10895 Protein ID WP_021242050.1
Coordinates 2297592..2298002 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag I6L60_RS10900 Protein ID WP_006178375.1
Coordinates 2297983..2298249 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L60_RS10875 (I6L60_10875) 2293585..2295318 - 1734 WP_069598757.1 single-stranded-DNA-specific exonuclease RecJ -
I6L60_RS10880 (I6L60_10880) 2295324..2296037 - 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6L60_RS10885 (I6L60_10885) 2296066..2296962 - 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
I6L60_RS10890 (I6L60_10890) 2297064..2297585 + 522 WP_069598758.1 flavodoxin FldB -
I6L60_RS10895 (I6L60_10895) 2297592..2298002 - 411 WP_021242050.1 protein YgfX Toxin
I6L60_RS10900 (I6L60_10900) 2297983..2298249 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
I6L60_RS10905 (I6L60_10905) 2298544..2299524 + 981 WP_045351721.1 tRNA-modifying protein YgfZ -
I6L60_RS10910 (I6L60_10910) 2299609..2300268 - 660 WP_021242052.1 hemolysin III family protein -
I6L60_RS10915 (I6L60_10915) 2300534..2301265 + 732 WP_008499714.1 MurR/RpiR family transcriptional regulator -
I6L60_RS10920 (I6L60_10920) 2301382..2302815 + 1434 WP_069598759.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T207156 WP_021242050.1 NZ_CP077407:c2298002-2297592 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T207156 NZ_CP102921:811876-812286 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCTCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTCGGGACGCCATGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT207156 WP_006178375.1 NZ_CP077407:c2298249-2297983 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207156 NZ_CP102921:811629-811895 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCTCGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TATTCAACTGGCTGATGAACCATGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References