Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 5548007..5548650 | Replicon | chromosome |
| Accession | NZ_CP077405 | ||
| Organism | Citrobacter braakii strain FDAARGOS 1421 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | - |
| Locus tag | I6L51_RS26865 | Protein ID | WP_080861356.1 |
| Coordinates | 5548007..5548423 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A0A1V8NRE0 |
| Locus tag | I6L51_RS26870 | Protein ID | WP_064396317.1 |
| Coordinates | 5548420..5548650 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6L51_RS26835 (I6L51_26835) | 5543045..5543731 | + | 687 | WP_217124989.1 | lytic transglycosylase domain-containing protein | - |
| I6L51_RS26840 (I6L51_26840) | 5543733..5544302 | + | 570 | WP_080861526.1 | integrating conjugative element protein | - |
| I6L51_RS26845 (I6L51_26845) | 5544310..5544537 | + | 228 | WP_143329773.1 | hypothetical protein | - |
| I6L51_RS26850 (I6L51_26850) | 5544534..5546735 | + | 2202 | WP_254170314.1 | type IV conjugative transfer system coupling protein TraD | - |
| I6L51_RS26855 (I6L51_26855) | 5546735..5547481 | + | 747 | WP_080861349.1 | TIGR03747 family integrating conjugative element membrane protein | - |
| I6L51_RS27305 | 5547726..5547902 | + | 177 | Protein_5260 | IS5/IS1182 family transposase | - |
| I6L51_RS26865 (I6L51_26865) | 5548007..5548423 | - | 417 | WP_080861356.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| I6L51_RS26870 (I6L51_26870) | 5548420..5548650 | - | 231 | WP_064396317.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| I6L51_RS26875 (I6L51_26875) | 5548817..5549124 | + | 308 | Protein_5263 | transposase | - |
| I6L51_RS26880 (I6L51_26880) | 5549534..5550265 | + | 732 | WP_158083404.1 | CZB domain-containing protein | - |
| I6L51_RS26885 (I6L51_26885) | 5550309..5550488 | + | 180 | WP_143329765.1 | hypothetical protein | - |
| I6L51_RS26890 (I6L51_26890) | 5550607..5550921 | + | 315 | WP_080861364.1 | RAQPRD family integrative conjugative element protein | - |
| I6L51_RS26895 (I6L51_26895) | 5550918..5551154 | + | 237 | WP_080861366.1 | TIGR03758 family integrating conjugative element protein | - |
| I6L51_RS26900 (I6L51_26900) | 5551205..5551546 | + | 342 | WP_249025186.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| I6L51_RS26905 (I6L51_26905) | 5551562..5551942 | + | 381 | WP_217124990.1 | TIGR03750 family conjugal transfer protein | - |
| I6L51_RS26910 (I6L51_26910) | 5551942..5552598 | + | 657 | WP_080861550.1 | TIGR03746 family integrating conjugative element protein | - |
| I6L51_RS26915 (I6L51_26915) | 5552619..5553500 | + | 882 | WP_254170325.1 | TIGR03749 family integrating conjugative element protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 5548874..5549134 | 260 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15020.36 Da Isoelectric Point: 6.7125
>T207146 WP_080861356.1 NZ_CP077405:c5548423-5548007 [Citrobacter braakii]
MIKTYMLDTNICSFIMREQPETVIKRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHGLLVEAFCARLDAILAWDRD
AVDATTEIKAALTAAGTSIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWAN
MIKTYMLDTNICSFIMREQPETVIKRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHGLLVEAFCARLDAILAWDRD
AVDATTEIKAALTAAGTSIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWAN
Download Length: 417 bp
>T207146 NZ_CP102898:c3879084-3878767 [Klebsiella quasipneumoniae]
ATGTTCAGAATGGTTGTGCACGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGGCCATTGTCCAGGCGAAGATGATCAG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGATAGTAAACCGCTGGGGCAGGGGCTATTCGAAA
TTCGGGCGTTAGGTTCGGTACAGGGGCGGGGGATTTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA
ATGTTCAGAATGGTTGTGCACGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGGCCATTGTCCAGGCGAAGATGATCAG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGATAGTAAACCGCTGGGGCAGGGGCTATTCGAAA
TTCGGGCGTTAGGTTCGGTACAGGGGCGGGGGATTTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8685.75 Da Isoelectric Point: 4.4563
>AT207146 WP_064396317.1 NZ_CP077405:c5548650-5548420 [Citrobacter braakii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFTQLEKADSDFMAERGDIVSDEGRFDL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFTQLEKADSDFMAERGDIVSDEGRFDL
Download Length: 231 bp
>AT207146 NZ_CP102898:c3878774-3878487 [Klebsiella quasipneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACGGAACTGCTCAGCCAGCCTGAGGTTCAGGCTGCGTTCGATGC
GCAAGAACGTCAACATCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTATTAA
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACGGAACTGCTCAGCCAGCCTGAGGTTCAGGCTGCGTTCGATGC
GCAAGAACGTCAACATCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|