Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 2883260..2883782 | Replicon | chromosome |
| Accession | NZ_CP077405 | ||
| Organism | Citrobacter braakii strain FDAARGOS 1421 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | I6L51_RS14330 | Protein ID | WP_080858538.1 |
| Coordinates | 2883501..2883782 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | I6L51_RS14325 | Protein ID | WP_080858539.1 |
| Coordinates | 2883260..2883511 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6L51_RS14295 (I6L51_14295) | 2879531..2879920 | - | 390 | WP_080858545.1 | antiterminator Q family protein | - |
| I6L51_RS14300 (I6L51_14300) | 2879923..2880219 | - | 297 | WP_080858544.1 | hypothetical protein | - |
| I6L51_RS14305 (I6L51_14305) | 2880216..2880818 | - | 603 | WP_080858543.1 | DUF1367 family protein | - |
| I6L51_RS14310 (I6L51_14310) | 2880882..2881460 | - | 579 | WP_080858542.1 | Rha family transcriptional regulator | - |
| I6L51_RS14315 (I6L51_14315) | 2881985..2882314 | + | 330 | WP_080858541.1 | hypothetical protein | - |
| I6L51_RS14320 (I6L51_14320) | 2882311..2883111 | - | 801 | WP_080858540.1 | hypothetical protein | - |
| I6L51_RS14325 (I6L51_14325) | 2883260..2883511 | + | 252 | WP_080858539.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| I6L51_RS14330 (I6L51_14330) | 2883501..2883782 | + | 282 | WP_080858538.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| I6L51_RS14335 (I6L51_14335) | 2883876..2884193 | + | 318 | WP_080858801.1 | DNA-binding transcriptional regulator | - |
| I6L51_RS14340 (I6L51_14340) | 2884280..2884792 | - | 513 | WP_080858537.1 | GNAT family N-acetyltransferase | - |
| I6L51_RS14345 (I6L51_14345) | 2884975..2885211 | - | 237 | WP_023222359.1 | hypothetical protein | - |
| I6L51_RS14350 (I6L51_14350) | 2885225..2885563 | - | 339 | WP_080858536.1 | hypothetical protein | - |
| I6L51_RS14355 (I6L51_14355) | 2885560..2886303 | - | 744 | WP_080858535.1 | DUF1627 domain-containing protein | - |
| I6L51_RS14360 (I6L51_14360) | 2886323..2887069 | - | 747 | WP_080858534.1 | ATP-binding protein | - |
| I6L51_RS27235 | 2887076..2887996 | - | 921 | WP_249025114.1 | DUF1376 domain-containing protein | - |
| I6L51_RS14370 (I6L51_14370) | 2888312..2888536 | + | 225 | WP_143329686.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | gtrB | 2836629..2902227 | 65598 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11088.92 Da Isoelectric Point: 10.4563
>T207141 WP_080858538.1 NZ_CP077405:2883501-2883782 [Citrobacter braakii]
MTYELKFERRAKKEWDKLGHPVREQFKKKLAERLENPHIPSARLHGRPNRYKIKLRSSGYRLVYDVIDDKLVLLVIVIGK
RAGNEVYELADER
MTYELKFERRAKKEWDKLGHPVREQFKKKLAERLENPHIPSARLHGRPNRYKIKLRSSGYRLVYDVIDDKLVLLVIVIGK
RAGNEVYELADER
Download Length: 282 bp
>T207141 NZ_CP102895:c10417-9887 [Klebsiella quasipneumoniae]
ATGGACGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATCAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTCACCGATCATCTGCAACGTCAGCACAGTAGTAAGATTTTACGGGGTTATCTGCTCGTGACGAGAGAGG
ATAGACCACGTGTCATGGGGTACTACACCCTGTCAGGCAGTTGCTTTGAGAAAATACTTCTCCCCAGCAAAACACAACAA
AAGCGTGTGCCCTACAAAAATGTGCCGAGCGTGACTTTGGGCCGTCTGGCAATTGATAAAAGCATTCATCACCAGGGATA
TGGAGAAACACTTGTTACCCATGCGATGAAAGTCGTGTATCAGGCCTCGCAGGCTGTGGGTATACACGGAATGTTCGTGG
AGGCGCTGAACGATAACGCCAAAAAATTCTACCTTCGACTGGGTTTTATACAGTTAAAGGAAGAAAACTGTGATTCGCTC
TTCTACCCGACAAAATCTATTGAAGTATTGTTCGAAGTAAATGACGAATAA
ATGGACGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATCAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTCACCGATCATCTGCAACGTCAGCACAGTAGTAAGATTTTACGGGGTTATCTGCTCGTGACGAGAGAGG
ATAGACCACGTGTCATGGGGTACTACACCCTGTCAGGCAGTTGCTTTGAGAAAATACTTCTCCCCAGCAAAACACAACAA
AAGCGTGTGCCCTACAAAAATGTGCCGAGCGTGACTTTGGGCCGTCTGGCAATTGATAAAAGCATTCATCACCAGGGATA
TGGAGAAACACTTGTTACCCATGCGATGAAAGTCGTGTATCAGGCCTCGCAGGCTGTGGGTATACACGGAATGTTCGTGG
AGGCGCTGAACGATAACGCCAAAAAATTCTACCTTCGACTGGGTTTTATACAGTTAAAGGAAGAAAACTGTGATTCGCTC
TTCTACCCGACAAAATCTATTGAAGTATTGTTCGAAGTAAATGACGAATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9151.31 Da Isoelectric Point: 3.7425
>AT207141 WP_080858539.1 NZ_CP077405:2883260-2883511 [Citrobacter braakii]
MTYQILTTIAASITDLKRNPMGTVADGEGNAVAILNRNEPAFYCVPPELYAYYIELAEDAELNAIADERMKDPDIVSVNL
DDL
MTYQILTTIAASITDLKRNPMGTVADGEGNAVAILNRNEPAFYCVPPELYAYYIELAEDAELNAIADERMKDPDIVSVNL
DDL
Download Length: 252 bp
>AT207141 NZ_CP102895:c10690-10421 [Klebsiella quasipneumoniae]
ATGTCAGCACTGAAGAAGCAGCGCATCGATCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCCATTTCGCAGTTCATGGTCAGTACCGCCTCAGCACGTGCTGCTGAAGTTATTGATCAGCACCGTCGCC
TGCTCCTCAATGAGGAGTCCTGGAATCTGGTTATGGATGCAATCACTAATCCGCCAGCACCAAATGACCGGCTGAAACGC
GCCACTAACCGTCTCCGGGAACTGGAGTAA
ATGTCAGCACTGAAGAAGCAGCGCATCGATCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCCATTTCGCAGTTCATGGTCAGTACCGCCTCAGCACGTGCTGCTGAAGTTATTGATCAGCACCGTCGCC
TGCTCCTCAATGAGGAGTCCTGGAATCTGGTTATGGATGCAATCACTAATCCGCCAGCACCAAATGACCGGCTGAAACGC
GCCACTAACCGTCTCCGGGAACTGGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|