Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 501759..502413 Replicon chromosome
Accession NZ_CP077405
Organism Citrobacter braakii strain FDAARGOS 1421

Toxin (Protein)


Gene name cptA Uniprot ID A0A7L6TYP6
Locus tag I6L51_RS02465 Protein ID WP_047357821.1
Coordinates 502006..502413 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag I6L51_RS02460 Protein ID WP_016154349.1
Coordinates 501759..502025 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L51_RS02435 (I6L51_02435) 496972..498405 - 1434 WP_080859192.1 6-phospho-beta-glucosidase BglA -
I6L51_RS02440 (I6L51_02440) 498526..499254 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
I6L51_RS02445 (I6L51_02445) 499307..499618 + 312 WP_016154352.1 N(4)-acetylcytidine aminohydrolase -
I6L51_RS02450 (I6L51_02450) 499782..500441 + 660 WP_016154351.1 hemolysin III family protein -
I6L51_RS02455 (I6L51_02455) 500521..501501 - 981 WP_047357823.1 tRNA-modifying protein YgfZ -
I6L51_RS02460 (I6L51_02460) 501759..502025 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
I6L51_RS02465 (I6L51_02465) 502006..502413 + 408 WP_047357821.1 protein YgfX Toxin
I6L51_RS02470 (I6L51_02470) 502514..503035 - 522 WP_016154347.1 flavodoxin FldB -
I6L51_RS02475 (I6L51_02475) 503149..504045 + 897 WP_016154346.1 site-specific tyrosine recombinase XerD -
I6L51_RS02480 (I6L51_02480) 504069..504782 + 714 WP_047357820.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6L51_RS02485 (I6L51_02485) 504788..506521 + 1734 WP_016157413.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15878.67 Da        Isoelectric Point: 11.5023

>T207132 WP_047357821.1 NZ_CP077405:502006-502413 [Citrobacter braakii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQARQG

Download         Length: 408 bp

>T207132 NZ_CP102893:785857-786267 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGTTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTAGTCTTTGACTGTG
TGCGTAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATCCCGGAGAGTGGCGGGATCTGCGCCGGTTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT207132 WP_016154349.1 NZ_CP077405:501759-502025 [Citrobacter braakii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207132 NZ_CP102893:785610-785876 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6TYP6

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References