Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxT-higA/Tad-HTH_37
Location 192085..192679 Replicon chromosome
Accession NZ_CP077405
Organism Citrobacter braakii strain FDAARGOS 1421

Toxin (Protein)


Gene name toxT Uniprot ID -
Locus tag I6L51_RS00890 Protein ID WP_080860924.1
Coordinates 192085..192405 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6L51_RS00895 Protein ID WP_080860922.1
Coordinates 192395..192679 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L51_RS00870 (I6L51_00870) 187562..188052 + 491 Protein_173 reverse transcriptase domain-containing protein -
I6L51_RS00875 (I6L51_00875) 188463..189872 + 1410 WP_080860928.1 group II intron reverse transcriptase/maturase -
I6L51_RS00880 (I6L51_00880) 190767..191627 + 861 WP_080860926.1 alpha/beta hydrolase -
I6L51_RS00885 (I6L51_00885) 191752..191943 + 192 Protein_176 IS110 family transposase -
I6L51_RS00890 (I6L51_00890) 192085..192405 + 321 WP_080860924.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L51_RS00895 (I6L51_00895) 192395..192679 + 285 WP_080860922.1 helix-turn-helix transcriptional regulator Antitoxin
I6L51_RS00910 (I6L51_00910) 193701..194495 - 795 WP_080860920.1 transcriptional regulator -
I6L51_RS00915 (I6L51_00915) 194482..194985 - 504 WP_080860918.1 CaiF/GrlA family transcriptional regulator -
I6L51_RS00920 (I6L51_00920) 195118..195864 - 747 WP_158083390.1 fimbrial protein -
I6L51_RS00925 (I6L51_00925) 196301..197053 - 753 WP_080860914.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 63548..207136 143588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12262.25 Da        Isoelectric Point: 9.2819

>T207131 WP_080860924.1 NZ_CP077405:192085-192405 [Citrobacter braakii]
MYELIFHPDAESEIYELEPVMQAKALKGLEKLEAKGPELRYPDTDIIDGGLFELRVGRKDITRTFFAYAKGRRIYILRTF
IKKTPKTPKAEIALAKSRWEELKDGS

Download         Length: 321 bp

>T207131 NZ_CP102891:c5195412-5195029 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
AGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10212.81 Da        Isoelectric Point: 9.6557

>AT207131 WP_080860922.1 NZ_CP077405:192395-192679 [Citrobacter braakii]
MAVKGIRFSEIKAKALANPEVKKAYEEETQEEELRAVLVEMKSKSGLTSTEIAARMGVSQPAVSRLERNVSSASLSTLQR
YAAACGMHIKLSLS

Download         Length: 285 bp

>AT207131 NZ_CP102891:c5195654-5195412 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References